Product Details
| Product Name:
GNE-8324 |
CAS No.:
1698901-76-6 |
| Purity:
99.34% |
Supply Ability:
10g |
| Release date:
2026/05/13 |
Product Introduction
Bioactivity
| Name | GNE-8324 |
| Description | GNE-8324 is a GluN2A selective positive allosteric modulator that selectively enhances NMDAR-mediated synaptic responses in inhibitory, but not excitatory, neurons.GNE-8324 is used in the study of neurological disorders. |
| In vitro | At GluN2A-type NMDARs, there is a reciprocal allosteric interaction between the binding sites for GNE-8324 and glutamate, meaning that glutamate binding promotes the binding of GNE-8324, and vice versa. GNE-8324 selectively enhances NMDARs containing the GluN2A subunit, with its potentiating effect significantly dependent on the occupancy of the glutamate site. The binding affinity of GNE-8324 is markedly higher in glutamate-bound NMDARs compared to those without bound glutamate. [1] |
| Storage | Keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (232.95 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (11.65 mM), Sonication is recommended.
|
| Keywords | NMDA | GNE-8324 |
| Inhibitors Related | Indole-2-carboxylic acid | Urethane | Decanoic Acid | N-Methylsarcosine | L-Glutamic acid | N,N-Dimethylglycine hydrochloride | Kynurenic acid | L-Phenylalanine | glycine | L-Glutamic acid monosodium salt | Memantine | Memantine hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Neurotransmitter Receptor Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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