一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Biochemical and Molecular Toxicology >>article
Journal of Biochemical and Molecular Toxicology

Journal of Biochemical and Molecular Toxicology

IF: 3.2
Download PDF

Study on the Effect of Naringenin on LPS-Induced Acute Lung Injury Based on NRF2/HO-1 Pathway

Published:4 June 2025 DOI: 10.1002/jbt.70333
Xiao-wei Wang, Da-gui Chen, Ci-an Zhang, Mu-yan Sun, Hao-hao Song, Chen-xi Zhang, Fu-sheng Shang, Min Ye

Abstract

Acute lung injury (ALI) is a serious respiratory disease characterized by pulmonary inflammatory cell infiltration and oxidative stress and is the leading cause of human death. Naringenin (NAR) is a naturally active flavonoid widely present in citrus fruits and has been shown to have multiple pharmacological effects. In this study, we evaluated the potential mechanism of NAR in lipopolysaccharide (LPS)-induced ALI by constructing a mice model of ALI. It was found that NAR significantly increased the 7-day survival rate of mice after LPS stimulation, improved lung index, tissue inflammatory infiltration, and fibrosis levels, and found that it decreased Interleukin-1 beta(IL-1β), Interleukin-6(IL-6), Tumor Necrosis Factor-alpha(TNF-α), and Malondialdehyde(MDA) levels in bronchoalveolar lavage fluid (BALF), while increasing Glutathione(GSH) and Superoxide Dismutase(SOD) levels. In addition, naringenin suppressed the expression of apoptotic proteins BCL2-Associated X Protein(BAX), Cysteine-Aspartate Protease 3(Caspase 3)and Cleaved-Caspase 3, promoted the expression of B-Cell Lymphoma 2(Bcl-2), and upregulated the expression of Nuclear Factor Erythroid 2-Related Factor 2(NRF2) and Heme Oxygenase-1(HO-1) in lung tissue. These studies suggest that naringenin ameliorates LPS-induced acute lung injury in mice by activating the NRF2/HO-1 pathway.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Naringenin 480-41-1 C15H12O5 566 suppliers $5.00-$10312.50
Naringenin 480-41-1 C15H12O5 566 suppliers $5.00-$10312.50
Naringenin 480-41-1 C15H12O5 566 suppliers $5.00-$10312.50
Naringenin 480-41-1 C15H12O5 566 suppliers $5.00-$10312.50
Naringenin 480-41-1 C15H12O5 - Inquiry
Naringenin 480-41-1 C15H12O5 - Inquiry

Similar articles

IF:5.3

HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS‐induced acute kidney injury

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Lili Huang, Yuanyuan Wu,etc Published: 25 November 2024
IF:4.8

The Benefits of Olive Oil for Skin Health: Study on the Effect of Hydroxytyrosol, Tyrosol, and Oleocanthal on Human Fibroblasts.

Nutrients Anabel González-Acedo, Javier Ramos-Torrecillas,etc Published: 25 April 2023
IF:10.7

A novel pH-responsive hydrogel based on carboxymethyl cellulose/2-hydroxyethyl acrylate for transdermal delivery of naringenin

Carbohydrate Polymers So Hyun Park, Hyuk Soo Shin,etc Published: 15 November 2018
邳州市| 邵东县| 泰和县| 鹤山市| 南城县| 泰和县| 松潘县| 凤阳县| 林周县| 新巴尔虎右旗| 海原县| 韶关市| 东乡族自治县| 饶河县| 万盛区| 故城县| 建德市| 宁海县| 黔江区| 金秀| 汉沽区| 洞头县| 胶州市| 诏安县| 赤壁市| 靖江市| 潞城市| 顺平县| 庐江县| 丰原市| 桑日县| 武汉市| 长岭县| 略阳县| 柳州市| 肇东市| 白水县| 册亨县| 肇州县| 阳信县| 龙江县|