鏈接：https://www.abinscience.cn/product/78/54997.html

名稱：Recombinant FMDV (SAT-1) VP1 Protein, N-His

Accession號：A0A7L4XQ62

貨號：VK500132

種屬：Foot-and-mouth disease virus SAT 1

表達系統(tǒng)：E. coli

狀態(tài)：Lyophilized

純度：>90% as determined by SDS-PAGE.

蛋白長度：Thr725-Gln943

應(yīng)用：ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

預(yù)測分子量 26.64 kDa

用途范圍：僅用于科研

儲存： Use ?a manual defrost freezer and avoid repeated freeze thaw cycles. Store ?at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months ?from the date of receipt.

產(chǎn)品介紹：近期，我國首次發(fā)生輸入性南非1型（SAT1）口蹄疫疫情，該血清型為非洲特有毒株，與我國長期流行的 ?O 型、A 型、亞洲 1 ?型等毒株在基因組、衣殼結(jié)構(gòu)、抗原蛋白組成及表位構(gòu)象上存在本質(zhì)區(qū)別，不同血清型間無交叉免疫保護，現(xiàn)有常規(guī)疫苗無法提供有效保護。

Recombinant ?FMDV (SAT-1) VP1 Protein, N-His ?(VK500132)是武漢艾必賽生物科技有限公司（abinScience）推出的一款高純度、高免疫原性的重組病毒蛋白。該產(chǎn)品為口蹄疫病毒（FMDV）南非1型（SAT-1）的衣殼蛋白VP1，攜帶N端組氨酸（His）標簽，采用大腸桿菌系統(tǒng)表達并純化。VP1蛋白是口蹄疫病毒的主要衣殼蛋白和關(guān)鍵抗原，負責病毒與宿主細胞受體的結(jié)合，并能誘導(dǎo)機體產(chǎn)生中和抗體，是研究病毒致病機制、開發(fā)診斷試劑及亞單位疫苗的核心原料。

產(chǎn)品購買聯(lián)系方式：027-87433958/17302791434

郵箱：info@abinscience.com

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參考文獻：

1. KIF5B-mediated internalization of FMDV promotes virus infection. PMID: 38499154

2. FMDV 3A Antagonizes the Effect of ANXA1 to Positively Modulate Viral Replication. PMID: 35604142

3. Cmss1 limits FMDV infection by enhancing antigen presentation and CD8(+) T cell responses. PMID: 41277842

4. ?A review of foot-and-mouth disease virus (FMDV) testing in livestock ?with an emphasis on the use of alternative diagnostic specimens. PMID: ?30345947

5. ?Foot-and-mouth disease virus (FMDV) negatively regulates ZFP36 protein ?expression to alleviate its antiviral activity. PMID: 39194213

6. FMDV Leader Protein Interacts with the NACHT and LRR Domains of NLRP3 to Promote IL-1beta Production. PMID: 35062226

7. MicroRNA-4331-5p promotes FMDV replication through inhibiting interferon pathways in PK-15 cells. PMID: 32574680

8. Multiple-Site SUMOylation of FMDV 3C Protease and Its Negative Role in Viral Replication. PMID: 36005757

9. ?Ribosomal protein L35 negatively regulates FMDV replication by ?recruiting AMFR to promote the ubiquitination and degradation of VP2. ?PMID: 41065387

10. ?3C(pro) of FMDV inhibits type II interferon-stimulated JAK-STAT ?signaling pathway by blocking STAT1 nuclear translocation. PMID: ?36921803

11. DDX56 cooperates with FMDV 3A to enhance FMDV replication by inhibiting the phosphorylation of IRF3. PMID: 31445188

12. ?Small Molecules Targeting 3C Protease Inhibit FMDV Replication and ?Exhibit Virucidal Effect in Cell-Based Assays. PMID: 37766293

13. Mutation of FMDV L(pro) H138 residue drives viral attenuation in cell culture and in vivo in swine. PMID: 36387381

14. ?The Host Protein CAD Regulates the Replication of FMDV through the ?Function of Pyrimidines' De Novo Synthesis. PMID: 37162335

15. ?Enhanced antigen-specific CD8 T cells contribute to early protection ?against FMDV through swine DC vaccination. PMID: 38289108

16. DDX21, a Host Restriction Factor of FMDV IRES-Dependent Translation and Replication. PMID: 34578346

17. RNA-Seq analysis reveals the different mechanisms triggered by bovine and equine after infection with FMDV. PMID: 39287214

18. ?Assessment on Different Vaccine Formulation Parameters in the ?Protection against Heterologous Challenge with FMDV in Cattle. PMID: ?36016403

19. Development of a competitive ELISA method based on VLPs detecting the antibodies of serotype A FMDV. PMID: 34915087

20. Phospholipase PLA2G16 Accelerates the Host Interferon Signaling Pathway Response to FMDV. PMID: 40733501

21. Susceptibility of primary ovine dorsal soft palate and palatine tonsil cells to FMDV infection. PMID: 39149149

22. Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity. PMID: 25835532

23. ?Development and Validation of Serotype-Specific Blocking ELISA for the ?Detection of Anti-FMDV O/A/Asia1/SAT2 Antibodies. PMID: 39339914

24. ?A genome-wide CRISPR screening uncovers that TOB1 acts as a key host ?factor for FMDV infection via both IFN and EGFR mediated pathways. PMID: ?38512977

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25. ?Unrecognized circulation of SAT 1 foot-and-mouth disease virus in ?cattle herds around Queen Elizabeth National Park in Uganda. PMID: ?26739166

26. Foot-and-mouth disease virus serotype SAT1 in cattle, Nigeria. PMID: 28224715

27. ?Meta-analysis of genetic diversity of VP1 gene of foot and mouth ?disease virus serotypes prevalent in Bangladesh from 2010 to 2024. PMID: ?41043698

28. The role of African buffalos (Syncerus caffer) in the maintenance of foot-and-mouth disease in Uganda. PMID: 21143994

29. ?Differentiation of the seven serotypes of foot-and-mouth disease virus ?by reverse transcriptase polymerase chain reaction. PMID: 9274816

30. ?Characterization of foot-and-mouth disease viruses (FMDVs) from Ugandan ?cattle outbreaks during 2012-2013: evidence for circulation of multiple ?serotypes. PMID: 25664876

31. ?Characterisation of recent foot-and-mouth disease viruses from African ?buffalo (Syncerus caffer) and cattle in Kenya is consistent with ?independent virus populations. PMID: 25644407

32. Molecular Characterization of Foot-and-Mouth Disease Viruses Collected in Tanzania Between 1967 and 2009. PMID: 24460931

33. ?Pervasive within-host recombination and epistasis as major determinants ?of the molecular evolution of the foot-and-mouth disease virus capsid. ?PMID: 31905219

34. ?Analysis of Recent Serotype O Foot-and-Mouth Disease Viruses from ?Livestock in Kenya: Evidence of Four Independently Evolving Lineages. ?PMID: 23931583

35. Capsid protein-encoding (P1) sequence of foot and mouth disease virus type Asia 1 ind 63/72. PMID: 10403702

36. Genetic heterogeneity in the foot-and-mouth disease virus Leader and 3C proteinases. PMID: 12036580

37. ?Demonstration of antigenic site 3 in foot-and-mouth disease virus ?serotype A using neutralizing monoclonal antibody resistant mutants. ?PMID: 41456690

38. Evidence for positive selection in foot-and-mouth disease virus capsid genes from field isolates. PMID: 11139487

39. ?Development and evaluation of tailored specific real-time RT-PCR assays ?for detection of foot-and-mouth disease virus serotypes circulating in ?East Africa. PMID: 27575682

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