鏈接：https://www.abinscience.cn/product/68/16504.html
名稱：InVivoMAb Anti-SEBOV/ZEBOV GP/Envelope glycoprotein Antibody (Iv0198)
貨號(hào)：VK623050
種屬反應(yīng)性：Ebola virus, Zaire ebolavirus, Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus), Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebolavirus)
應(yīng)用：ELISA, FCM, Neutralization
宿主：Human
同種型：IgG
克隆號(hào)：Iv0198
克隆類型：Monoclonal
靶標(biāo)：Envelope glycoprotein, GP1, 2, GP, Shed GP, GP1, 2-delta, GP1, GP2, GP
內(nèi)毒素水平：Please contact with the lab for this information.
純度：>95% as determined by SDS-PAGE.
純化方式：Protein A/G purified from cell culture supernatant.
Accession號(hào)：P87666, O11457, Q05320, Q9YMG2, P0C773, Q7T9D9
狀態(tài)：Liquid
用途范圍：僅用于科研
儲(chǔ)存：Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
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產(chǎn)品介紹：InVivoMAb Anti-SEBOV/ZEBOV GP/Envelope glycoprotein Antibody (Iv0198)｜VK623050 是艾必賽生物（abinScience）推出的人源單克隆抗體（人 IgG），靶向扎伊爾埃博拉病毒（ZEBOV, strain Mayinga-76）與蘇丹埃博拉病毒（SEBOV, Gulu/2000）的包膜糖蛋白 GP，可同時(shí)交叉識(shí)別兩種高危埃博亞型，適用于 ELISA、流式（FCM）及中和實(shí)驗(yàn)（Neutralization），也可作為體內(nèi)（In Vivo）研究級(jí)抗體使用。該抗體經(jīng) Protein A/G 純化，純度 >95%（SDS-PAGE），以液體形式保存在 0.01M PBS, pH 7.4 中；短期 4°C（1–2 周），長(zhǎng)期建議 -20°C（≤12 個(gè)月）/ -80°C 避反復(fù)凍融。（RUO，僅限科研/非臨床用途）
埃博拉病毒歸類于絲狀病毒科，為單股負(fù)鏈 RNA 病毒，其中扎伊爾型（ZEBOV）致死率最高（可 >50%），蘇丹型（SEBOV）亦具高致病性。人際傳播以接觸患者/死者血液、體液及污染物為主，早期表現(xiàn)為高熱、肌痛、胃腸癥狀，重癥進(jìn)展為血管內(nèi)皮損傷、凝血障礙、多器官衰竭及出血。病毒表面 GP（GP1,2）三聚體刺突通過(guò) GP1 結(jié)合宿主受體（如 NPC1 通路）、GP2 介導(dǎo)膜融合完成入侵，同時(shí) GP 還可下調(diào)整合素表達(dá)、擾亂免疫監(jiān)視，是中和抗體、抗病毒藥物及疫苗的核心靶點(diǎn)。Iv0198 能同時(shí)覆蓋 ZEBOV 與 SEBOV 兩種 GP，適合用于跨毒株血清學(xué)檢測(cè)、流式分型、中和效價(jià)評(píng)估及體內(nèi)保護(hù)實(shí)驗(yàn)的方法搭建與對(duì)照設(shè)置。
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產(chǎn)品購(gòu)買聯(lián)系方式：027-87433958/17302791434
郵箱：info@abinscience.com
參考文獻(xiàn)：
Structures and Functions of the Envelope Glycoprotein in Flavivirus Infections. PMID: 29137162
Maturation of HIV envelope glycoprotein precursors by cellular endoproteases. PMID: 11063880
Single-molecule localisation microscopy approaches reveal envelope glycoprotein clusters in single-enveloped viruses: a potential functional role? PMID: 40495469
Viral envelope glycoprotein processing by proprotein convertases. PMID: 23611717
Postfusion structure of human-infecting Bourbon virus envelope glycoprotein. PMID: 31419524
Mapping glycoprotein structure reveals Flaviviridae evolutionary history. PMID: 39232167
Characterization of the dengue virus envelope glycoprotein expressed in Pichia pastoris. PMID: 17502678
Alpharetrovirus envelope-receptor interactions. PMID: 12932076
Enveloped viruses. PMID: 13677053
Envelope proteins as antiviral drug target. PMID: 32643453
Human cytomegalovirus glycoproteins. PMID: 9130049
IFITM1 and IFITM3 Proteins Inhibit the Infectivity of Progeny HIV-1 without Disrupting Envelope Glycoprotein Clusters. PMID: 38140631
Human immunodeficiency virus type 1 envelope glycoprotein is modified by O-linked oligosaccharides. PMID: 8254757
Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1. PMID: 3629244
Virus glycoprotein nanodisc platform for vaccine analytics. PMID: 41667448
Budding of alphaviruses. PMID: 15567491
The SARS-CoV S glycoprotein. PMID: 15526150
Extracellular vaccinia virus envelope glycoprotein encoded by the A33R gene. PMID: 8648710
Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain. PMID: 38299743
MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation. PMID: 32934085
Rat and human cytomegalovirus ORF116 encodes a virion envelope glycoprotein required for infectivity. PMID: 33601113
Guanylate-binding protein 5 antagonizes viral glycoproteins independently of furin processing. PMID: 39212413
Assembly of a functional HCV glycoprotein heterodimer. PMID: 17489436
Averaging of viral envelope glycoprotein spikes from electron cryotomography reconstructions using Jsubtomo. PMID: 25350719
MARCH8 Targets Cytoplasmic Lysine Residues of Various Viral Envelope Glycoproteins. PMID: 35019698
Research Note: Duck plague virus glycoprotein I influences cell-cell spread and final envelope acquisition. PMID: 33248580
Assays to Assess Arenaviral Glycoprotein Function. PMID: 28986832
Biochemical reconstitution of hemorrhagic-fever arenavirus envelope glycoprotein-mediated membrane fusion. PMID: 23226473
Functional Relevance of the N-Terminal Domain of Pseudorabies Virus Envelope Glycoprotein H and Its Interaction with Glycoprotein L. PMID: 28228592
Assembly of arenavirus envelope glycoprotein GPC in detergent-soluble membrane microdomains. PMID: 19625404
Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation. PMID: 14963486
Analysis of the humoral immune response against the envelope glycoprotein Gc of Schmallenberg virus reveals a domain located at the amino terminus targeted by mAbs with neutralizing activity. PMID: 26684324
Characterization of human immunodeficiency virus type 2 envelope glycoproteins: dimerization of the glycoprotein precursor during processing. PMID: 2911118
Targeting retroviral and lentiviral vectors. PMID: 12932077
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