Product Name：Zilucoplan
CAS No.：1841136-73-9
Synonyms：抑制劑多肽Zilucoplan
Catalog No.：220P174
Brand：Typeptide Biotech（肽研生物）
Description：Zilucoplan是一種15個(gè)氨基酸的大環(huán)肽，同時(shí)也是有效的補(bǔ)體成分 5 (C5) 抑制劑多肽，能特異性的靶向末端補(bǔ)體激活途徑的組分C5，從而防止C5被C5轉(zhuǎn)化酶裂解為補(bǔ)體成分C5a和C5b，進(jìn)而阻止膜攻擊復(fù)合物（MAC）的下游組裝和活性。Zilucoplan可用于免疫介導(dǎo)的壞死性肌病 (IMNM) 以及全身性重癥肌無(wú)力（gMG）的相關(guān)研究。
Zilucoplan is a 15 amino acid macrocyclic peptide and an effective complement component 5 (C5) inhibitor polypeptide. It can specifically target the component C5 of the terminal complement activation pathway, thereby preventing C5 from being cleaved by C5 convertase into complement components C5a and C5b, and thus preventing downstream assembly and activity of membrane attack complexes (MACs). Zilucoplan can be used for research on immune-mediated necrotizing myopathy (IMNM) and systemic myasthenia gravis (gMG).
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | Ac-KVERFD-{N-Me-Asp}-Tle-Y-{3-(1H-PYRROLO(2,3-B)PYRIDIN-3-YL)-L-ALANYL}-EYP-Cha-Lys（C16-β-Asp-Peg24）(Chemical Bridge Lys1-Asp6) |
Sequence(3-letter code) | Ac-Lys-Val-Glu-Arg-Phe-Asp-{N-Me-Asp}-Tle-Tyr-{3-(1H-PYRROLO(2,3-B)PYRIDIN-3-YL)-L-ALANYL}-Glu-Tyr-Pro-Cha-Lys（C16-β-Asp-Peg24）(Chemical Bridge Lys1-Asp6) |
Peptide Structure | 
|
Molecular Formula | C172H278N24O55 |
Molecular Weight | 3562.18 |
訂購(gòu)聯(lián)系方式：
南京肽研生物生物科技有限公司
手機(jī)號(hào)：19961912513(微信同號(hào))
QQ: 2178255659
郵箱：sales@typeptide.com
聯(lián)系人：顧經(jīng)理
申明：本產(chǎn)品僅供科研使用，不得用于人體。
關(guān)鍵字： Zilucoplan;抑制劑多肽Zilucoplan;1841136-73-9;多肽;多肽合成;
肽研生物坐落于國(guó)家級(jí)新區(qū)南京江北新區(qū)新材料產(chǎn)業(yè)園，是一家專(zhuān)業(yè)從事多肽產(chǎn) 品的研發(fā)、生產(chǎn)和銷(xiāo)售以及多肽技術(shù)轉(zhuǎn)讓的高新技術(shù)企業(yè)。公司秉持“誠(chéng)信、嚴(yán) 謹(jǐn)、務(wù)實(shí)”的匠人精神，持續(xù)投入研發(fā)，不斷創(chuàng)新，致力于為科研工作者提供豐 富全面的多肽修飾類(lèi)型和優(yōu)質(zhì)的產(chǎn)品。