Product Name：Nogo-66 (1-40)
CAS No.：475221-20-6
Synonyms：抑制劑多肽Nogo-66 (1-40)
Catalog No.：218P071
Brand：Typeptide Biotech（肽研生物）
Description：Nogo-66 (1-40)是對應(yīng)于Nogo-66的殘基1-40的多肽，序列中含有40個氨基酸，肽鏈兩端均被封閉，Nogo-66是抑制軸突生長的髓鞘蛋白Nogo的結(jié)構(gòu)域。作為Nogo-66受體(NgR)的競爭性拮抗劑，能阻斷Nogo-66和CNS髓鞘誘導(dǎo)的軸突生長抑制，但在體外不降低髓鞘相關(guān)糖蛋白(MAG)對軸突生長的抑制。Nogo-66 (1-40)在體內(nèi)脊髓損傷后促進(jìn)半切脊髓軸突的再生和運(yùn)動恢復(fù)。
Nogo-66 (1-40) is a peptide corresponding to residues 1-40 of Nogo-66, containing 40 amino acids in its sequence. Both ends of the peptide chain are blocked, and Nogo-66 is the domain of Nogo, a myelin protein that inhibits axonal growth. As a competitive antagonist of Nogo-66 receptor (NgR), it can block Nogo-66 and CNS myelin induced axonal growth inhibition, but does not reduce the inhibition of myelin associated glycoprotein (MAG) on axonal growth in vitro. Nogo-66 (1-40) promotes regeneration and motor recovery of semi cut spinal cord axons after spinal cord injury in vivo.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 |
Sequence(3-letter code) | Ac-Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH2 |
Peptide Structure | 
|
Molecular Formula | C206H324N56O65 |
Molecular Weight | 4625.18 |
訂購聯(lián)系方式：
南京肽研生物生物科技有限公司
手機(jī)號：19961912513(微信同號)
QQ: 2178255659
郵箱：sales@typeptide.com
聯(lián)系人：顧經(jīng)理
申明：本產(chǎn)品僅供科研使用，不得用于人體。
關(guān)鍵字： Nogo-66 (1-40);抑制劑多肽Nogo-66 (1-40);475221-20-6;多肽;多肽合成;
肽研生物坐落于國家級新區(qū)南京江北新區(qū)新材料產(chǎn)業(yè)園，是一家專業(yè)從事多肽產(chǎn) 品的研發(fā)、生產(chǎn)和銷售以及多肽技術(shù)轉(zhuǎn)讓的高新技術(shù)企業(yè)。公司秉持“誠信、嚴(yán) 謹(jǐn)、務(wù)實(shí)”的匠人精神，持續(xù)投入研發(fā)，不斷創(chuàng)新，致力于為科研工作者提供豐 富全面的多肽修飾類型和優(yōu)質(zhì)的產(chǎn)品。