Product Name：TREM-1 inhibitory peptide GF9
CAS No.：1289375-12-7
Synonyms：抑制劑多肽Human TREM-1(213-221)
Catalog No.：220P372
Brand：Typeptide Biotech（肽研生物）
Description：TREM-1 inhibitory peptide GF9是一種 TREM-1 抑制劑多肽，是由9個(gè)氨基酸組成的多肽。TREM-1 inhibitory peptide GF9 通過(guò)不依賴配體的機(jī)制阻斷 TREM-1 信號(hào)通路，可自發(fā)插入細(xì)胞膜使 TREM-1 與 DAP-12 分離，并通過(guò)信號(hào)鏈同源寡聚化 (SCHOOL) 模型發(fā)揮作用。TREM-1 inhibitory peptide GF9 可降低 TNFα，IL-1β，IL-6，M-CSF 水平。TREM-1 inhibitory peptide GF9 可抑制腫瘤生長(zhǎng)，延長(zhǎng)胰腺癌模型小鼠的生存期，并改善膠原誘導(dǎo)性關(guān)節(jié)炎，同時(shí)發(fā)揮骨與軟骨保護(hù)作用。TREM-1 inhibitory peptide GF9 可用于關(guān)節(jié)炎、胰腺癌、視網(wǎng)膜病變、酒精性肝病及肝癌的相關(guān)研究。
TREM-1 inhibitory peptide GF9 is a TREM-1 inhibitor peptide composed of 9 amino acids. TREM-1 inhibitory peptide GF9 blocks the TREM-1 signaling pathway through a ligand independent mechanism, and can spontaneously insert into the cell membrane to separate TREM-1 from DAP-12, exerting its effect through the signal chain homooligomerization (SCHOOL) model. TREM-1 inhibitory peptide GF9 can reduce the levels of TNF α, IL-1 β, IL-6, and M-CSF. TREM-1 inhibitor GF9 can inhibit tumor growth, prolong the survival period of pancreatic cancer model mice, improve collagen induced arthritis, and play the role of bone and cartilage protection. TREM-1 inhibitor GF9 can be used in the research of arthritis, pancreatic cancer, retinopathy, alcoholic liver disease and liver cancer.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | GFLSKSLVF |
Sequence(3-letter code) | H-Gly-Phe-Leu-Ser-Lys-Ser-Leu-Val-Phe-OH |
Peptide Structure | 
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Molecular Formula | C49H76N10O12 |
Molecular Weight | 997.19 |
訂購(gòu)聯(lián)系方式：
南京肽研生物生物科技有限公司
手機(jī)號(hào)：19961912513(微信同號(hào))
QQ: 2178255659
郵箱：sales@typeptide.com
聯(lián)系人：顧經(jīng)理
申明：本產(chǎn)品僅供科研使用，不得用于人體。
關(guān)鍵字： TREM-1 inhibitory pe;抑制劑多肽Human TREM-1(21;1289375-12-7;多肽;多肽合成;
肽研生物坐落于國(guó)家級(jí)新區(qū)南京江北新區(qū)新材料產(chǎn)業(yè)園，是一家專業(yè)從事多肽產(chǎn) 品的研發(fā)、生產(chǎn)和銷售以及多肽技術(shù)轉(zhuǎn)讓的高新技術(shù)企業(yè)。公司秉持“誠(chéng)信、嚴(yán) 謹(jǐn)、務(wù)實(shí)”的匠人精神，持續(xù)投入研發(fā)，不斷創(chuàng)新，致力于為科研工作者提供豐 富全面的多肽修飾類型和優(yōu)質(zhì)的產(chǎn)品。