一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cell reports >>article
Cell reports

Cell reports

IF: 7.5
Download PDF

Mitochondrial cristae architecture protects against mtDNA release and inflammation.

Published:6 December 2022 DOI: 10.1016/j.celrep.2022.111774 PMID: 36476853
Baiyu He, Huatong Yu, Shanshan Liu, Huayun Wan, Song Fu, Siqi Liu, Jun Yang, Zihan Zhang, Huanwei Huang, Qi Li, Fengchao Wang, Zhaodi Jiang, Qinghua Liu, Hui Jiang

Abstract

Mitochondrial damage causes mitochondrial DNA (mtDNA) release to activate the type I interferon (IFN-I) response via the cGAS-STING pathway. mtDNA-induced inflammation promotes autoimmune- and aging-related degenerative disorders. However, the global picture of inflammation-inducing mitochondrial damages remains obscure. Here, we have performed a mitochondria-targeted CRISPR knockout screen for regulators of the IFN-I response. Strikingly, our screen reveals dozens of hits enriched with key regulators of cristae architecture, including phospholipid cardiolipin and protein complexes such as OPA1, mitochondrial contact site and cristae organization (MICOS), sorting and assembly machinery (SAM), mitochondrial intermembrane space bridging (MIB), prohibitin (PHB), and the F1Fo-ATP synthase. Disrupting these cristae organizers consistently induces mtDNA release and the STING-dependent IFN-I response. Furthermore, knocking out MTX2, a subunit of the SAM complex whose null mutations cause progeria in humans, induces a robust STING-dependent IFN-I response in mouse liver. Taken together, beyond revealing the central role of cristae architecture to prevent mtDNA release and inflammation, our results mechanistically link mitochondrial cristae disorganization and inflammation, two emerging hallmarks of aging and aging-related degenerative diseases.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
N-(4-chlorophenyl)-4-hydroxy-3-(4-(4-(trifluoromethoxy)phenyl)piperazin-1-yl)butanamide 2086257-77-2 C21H23ClF3N3O3 42 suppliers Inquiry
N-(4-chlorophenyl)-4-hydroxy-3-(4-(4-(trifluoromethoxy)phenyl)piperazin-1-yl)butanamide 2086257-77-2 C21H23ClF3N3O3 42 suppliers Inquiry
N-(4-chlorophenyl)-4-hydroxy-3-(4-(4-(trifluoromethoxy)phenyl)piperazin-1-yl)butanamide 2086257-77-2 C21H23ClF3N3O3 42 suppliers Inquiry
N-(4-chlorophenyl)-4-hydroxy-3-(4-(4-(trifluoromethoxy)phenyl)piperazin-1-yl)butanamide 2086257-77-2 C21H23ClF3N3O3 42 suppliers Inquiry

Similar articles

IF:5.4

Testosterone-induced effects on lipids and inflammation.

ACS Applied Energy Materials Stella Vodo,?Nicoletta Bechi,etc Published: 1 January 2013
IF:0

Encapsulation of Cinnamaldehyde using Chitosan: Stability, Mucoadhesive and Cinnamaldehyde Release

Jurnal Kimia Sains dan Aplikasi P. R. Sarjono,?N. Ngadiwiyana,etc Published: 24 October 2018
IF:5.3

HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS‐induced acute kidney injury

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Lili Huang, Yuanyuan Wu,etc Published: 25 November 2024
凌云县| 都昌县| 静宁县| 阳山县| 梁河县| 镇原县| 西乌珠穆沁旗| 丹巴县| 米脂县| 安徽省| 东辽县| 黎城县| 宜阳县| 静海县| 赣榆县| 麻城市| 祁连县| 定南县| 九龙城区| 雷波县| 温宿县| 天津市| 繁峙县| 东乡县| 尖扎县| 乌鲁木齐县| 揭西县| 连山| 阿巴嘎旗| 拜泉县| 唐海县| 酒泉市| 宾阳县| 新干县| 突泉县| 安西县| 阿拉善盟| 金阳县| 响水县| 宜州市| 江都市|