一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> International Journal of Molecular Sciences >>article
International Journal of Molecular Sciences

International Journal of Molecular Sciences

IF: 5.6
Download PDF

The Mechanism of Tigecycline Resistance in Acinetobacter baumannii under Sub-Minimal Inhibitory Concentrations of Tigecycline

Published:2 February 2024 DOI: 10.3390/ijms25031819
Cunwei Liu, Jia Liu, Qinghui Lu, Ping Wang, Qinghua Zou

Abstract

The presence of sub-minimal inhibitory concentration (sub-MIC) antibiotics in our environment is widespread, and their ability to induce antibiotic resistance is inevitable. Acinetobacter baumannii, a pathogen known for its strong ability to acquire antibiotic resistance, has recently shown clinical resistance to the last-line antibiotic tigecycline. To unravel the complex mechanism of A. baumannii drug resistance, we subjected tigecycline-susceptible, -intermediate, and -mildly-resistant strains to successive increases in sub-MIC tigecycline and ultimately obtained tigecycline-resistant strains. The proteome of both key intermediate and final strains during the selection process was analyzed using nanoLC-MS/MS. Among the more than 2600 proteins detected in all strains, we found that RND efflux pump AdeABC was associated with the adaptability of A. baumannii to tigecycline under sub-MIC pressure. qRT-PCR analysis also revealed higher expression of AdeAB in strains that can quickly acquire tigecycline resistance compared with strains that displayed lower adaptability. To validate our findings, we added an efflux pump inhibitor, carbonyl cyanide m-chlorophenyl hydrazine (CCCP), to the medium and observed its ability to inhibit tigecycline resistance in A. baumannii strains with quick adaptability. This study contributes to a better understanding of the mechanisms underlying tigecycline resistance in A. baumannii under sub-MIC pressure.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE 555-60-2 C9H5ClN4 218 suppliers $16.00-$1900.00
CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE 555-60-2 C9H5ClN4 218 suppliers $16.00-$1900.00
CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE 555-60-2 C9H5ClN4 218 suppliers $16.00-$1900.00
CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE 555-60-2 C9H5ClN4 218 suppliers $16.00-$1900.00

Similar articles

IF:12.2

High Temperatures Promote Antibiotic Resistance Genes Conjugative Transfer under Residual Chlorine: Mechanisms and Risks

Journal of Hazardous Materials Wenya Zhao, Binghuang Zhang,etc Published: 26 November 2024
多伦县| 陇南市| 洪湖市| 西峡县| 凤阳县| 镇江市| 镇江市| 东乡族自治县| 仪陇县| 邵阳县| 浪卡子县| 东辽县| 金沙县| 泰和县| 南华县| 临潭县| 罗城| 波密县| 乳山市| 太仓市| 泌阳县| 新乐市| 天镇县| 三门县| 东至县| 绩溪县| 巴彦县| 铁岭县| 敖汉旗| 固安县| 轮台县| 霍林郭勒市| 宿松县| 凌源市| 达日县| 唐山市| 岚皋县| 景洪市| 金门县| 华池县| 镇沅|