一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> International Journal of Molecular Sciences >>article
International Journal of Molecular Sciences

International Journal of Molecular Sciences

IF: 5.6
Download PDF

Nuclear Binding Protein 2/Nesfatin-1 Affects Trophoblast Cell Fusion during Placental Development via the EGFR-PLCG1-CAMK4 Pathway

Published:5 February 2024 DOI: 10.3390/ijms25031925 PMID: 38339201
Qinyu Dang,?Yandi Zhu,?Yadi Zhang,?Zhuo Hu,?Yuchen Wei,?Zhaoyang Chen,?Xinyin Jiang,?Xiaxia Cai,?Huanling Yu

Abstract

Previous studies have shown that nuclear binding protein 2 (NUCB2) is expressed in the human placenta and increases with an increase in the syncytialization of trophoblast cells. This study aimed to investigate the role of NUCB2 in the differentiation and fusion of trophectoderm cells. In this study, the expression levels of NUCB2 and E-cadherin in the placentas of rats at different gestation stages were investigated. The results showed that there was an opposite trend between the expression of placental NUCB2 and E-cadherin in rat placentas in different trimesters. When primary human trophoblast (PHT) and BeWo cells were treated with high concentrations of Nesfatin-1, the trophoblast cell syncytialization was significantly inhibited. The effects of NUCB2 knockdown in BeWo cells and Forskolin-induced syncytialization were investigated. These cells showed a significantly decreased cell fusion rate. The mechanism underlying NUCB2-regulated trophoblast cell syncytialization was explored using RNA-Seq and the results indicated that the epidermal growth factor receptor (EGFR)-phospholipase C gamma 1 (PLCG1)-calmodulin-dependent protein kinase IV (CAMK4) pathway might be involved. The results suggested that the placental expression of NUCB2 plays an important role in the fusion of trophoblasts during differentiation via the EGFR-PLCG1-CAMK4 pathway.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Forskolin 66575-29-9 C22H34O7 536 suppliers $12.00-$3200.00
Forskolin 66575-29-9 C22H34O7 536 suppliers $12.00-$3200.00
Forskolin 66575-29-9 C22H34O7 536 suppliers $12.00-$3200.00
Forskolin 66575-29-9 C22H34O7 536 suppliers $12.00-$3200.00
Forskolin 66575-29-9 - Inquiry
Forskolin 66575-29-9 - Inquiry
Forskolin 66575-29-9 C22H34O7 - Inquiry
Forskolin 66575-29-9 C22H34O7 - Inquiry

Similar articles

IF:2.6

Sphingosine-1-phosphate receptor 3 promotes neuronal apoptosis via the TNF-α/caspase-3 signaling pathway after acute intracerebral hemorrhage

Molecular and Cellular Neuroscience Dengpan Song, Mengyuan Li,etc Published: 22 November 2024
IF:9.6

EGFR exon 20 insertions in advanced non-small cell lung cancer: A new history begins

Cancer treatment reviews Jordi Remon , Lizza E.L. Hendriks ,etc Published: 1 November 2020
IF:5.4

Determination of 2-Acetyl-1-pyrroline via a Color-Change Reaction Using Chromium Hexacarbonyl.

ACS Applied Energy Materials Chonlada Bennett, Woraprapa Sriyotai,etc Published: 20 June 2022
凤庆县| 开封市| 东乌珠穆沁旗| 贵定县| 达州市| 榆中县| 盈江县| 青龙| 手机| 鹿泉市| 沙坪坝区| 阿鲁科尔沁旗| 昌吉市| 和顺县| 随州市| 信阳市| 沐川县| 大悟县| 海南省| 三穗县| 巴马| 化州市| 望都县| 平原县| 旌德县| 巫山县| 东安县| 柘荣县| 佳木斯市| 东方市| 临泉县| 南京市| 印江| 钟祥市| 博野县| 兰州市| 南丹县| 昭通市| 大丰市| 蒲城县| 启东市|