一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> FASEB Journal >>article
FASEB Journal

FASEB Journal

IF: 4.4
Download PDF

Scutellarin alleviates renal ischemia–reperfusion injury by inhibiting the MAPK pathway and pro-inflammatory macrophage polarization

Published:3 July 2024 DOI: 10.1096/fj.202302243R PMID: 38958951
Ge Deng, Bingxuan Zheng, Meng Dou, Yang Gao, Xingzhe Zhang, Zejiaxin Niu, Tian Wei, Feng Han, Chenguang Ding, Puxun Tian

Abstract

Renal ischemia–reperfusion injury (IRI) is an integral process in renal transplantation, which results in compromised graft survival. Macrophages play an important role in both the early inflammatory period and late fibrotic period in response to IRI. In this study, we investigated whether scutellarin (SCU) could protect against renal IRI by regulating macrophage polarization. Mice were given SCU (5–50?mg/kg) by gavage 1?h earlier, followed by a unilateral renal IRI. Renal function and pathological injury were assessed 24?h after reperfusion. The results showed that administration of 50?mg/kg SCU significantly improved renal function and renal pathology in IRI mice. In addition, SCU alleviated IRI-induced apoptosis. Meanwhile, it reduced macrophage infiltration and inhibited pro-inflammatory macrophage polarization. Moreover, in RAW 264.7 cells and primary bone marrow-derived macrophages (BMDMs) exposed to SCU, we found that 150?μM SCU inhibited these cells to polarize to an inflammatory phenotype induced by lipopolysaccharide (LPS) and interferon-γ (IFN-γ). However, SCU has no influence on anti-inflammatory macrophage polarization in vivo and in vitro induced by in interleukin-4 (IL-4). Finally, we explored the effect of SCU on the activation of the mitogen-activated protein kinase (MAPK) pathway both in vivo and in vitro. We found that SCU suppressed the activation of the MAPK pathway, including the extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK), and p38. Our results demonstrated that SCU protects the kidney against IRI by inhibiting macrophage infiltration and polarization toward pro-inflammatory phenotype via the MAPK pathway, suggesting that SCU may be therapeutically important in treatment of IRI.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Scutellarin 27740-01-8 C21H18O12 363 suppliers $22.00-$1647.00
Scutellarin 27740-01-8 C21H18O12 363 suppliers $22.00-$1647.00
Scutellarin 27740-01-8 C21H18O12 363 suppliers $22.00-$1647.00
Scutellarin 27740-01-8 C21H18O12 363 suppliers $22.00-$1647.00

Similar articles

IF:3

Neuroprotective effects of phenylacetylglycine via β2AR on cerebral ischemia/reperfusion injury in rats

Saudi Pharmaceutical Journal Wenjie Hu, Xueyan Kuang,etc Published: 1 December 2024
IF:5.3

BMP10 Knockdown Modulates Endothelial Cell Immunoreactivity by Inhibiting the HIF‐1α Pathway in the Sepsis‐Induced Myocardial Injury

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Huan Guan, Jingyun Fang,etc Published: 29 November 2024
IF:5.3

HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS‐induced acute kidney injury

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Lili Huang, Yuanyuan Wu,etc Published: 25 November 2024
平泉县| 汤原县| 青岛市| 丹东市| 沅江市| 大冶市| 乌拉特后旗| 大连市| 武安市| 闵行区| 靖远县| 红安县| 漯河市| 盈江县| 沙坪坝区| 建阳市| 鲜城| 云和县| 社旗县| 泾源县| 韩城市| 通州区| 信宜市| 武功县| 镇沅| 砚山县| 道孚县| 洪雅县| 安吉县| 玉田县| 喀喇沁旗| 陕西省| 水城县| 闽侯县| 北辰区| 尚志市| 东兰县| 库伦旗| 桐柏县| 历史| 金湖县|