一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Mammalian Genome >>article
Mammalian Genome

Mammalian Genome

IF: 2.7
Download PDF

Biological mechanism and functional verification of key genes related to major depressive disorder and type 2 diabetes mellitus

Published:10 December 2024 DOI: 10.1007/s00335-024-10090-z PMID: 39656235
Tao Fang,?Na Shen,?Zhemin Shi,?Weishun Luo,?Yanbo Di,?Xuan Liu,?Shengnan Ma,?Jing Wang,?Shike Hou

Abstract

Major depressive disorder (MDD) and type 2 diabetes (T2D) have been shown to be linked, but a comprehensive understanding of the underlying molecular mechanisms remains elusive. The purpose of this study was to explore the biological relationship between MDD and T2D and verify the functional roles of key genes. We used the Gene Expression Omnibus database to investigate the targets associated with MDD and T2D. Using linear models for microarray data, differentially expressed genes associated with MDD and T2D were identified in GSE76826 and GSE95849, respectively, and 126 shared genes were significantly upregulated. Weighted gene coexpression network analysis identified modules associated with MDD and T2D in the GSE38206 and GSE20966 datasets and identified 8 common genes. Functional enrichment analysis revealed that these genes were enriched in cell signaling, enzyme activity, cell structure and amino acid biosynthesis and involved in cell death pathways. Finally, combined with the CTD and GeneCards databases, lysophosphatidylglycerol acyltransferase 1 (LPGAT1) was identified as a key gene. LPGAT1 was validated in GSE201332 and GSE182117, and the subject operating characteristic curve showed good diagnostic potential for MDD and T2D. Additionally, we used an in vitro model of MDD related to T2D to verify the expression of LPGAT1. A subsequent gene knockdown assay revealed that the downregulation of LPGAT1 improved mitochondrial function and reduced apoptosis in damaged neurons. Taken together, our results highlight the role of LPGAT1 in the connection between MDD and T2D, and these findings provide new insights into potential therapeutic targets for depression associated with diabetes.

Substances (1)

Materials
Procduct Name CAS Molecular Formula Supplier Price
CORTICOSTERONE 50-22-6 C21H30O4 336 suppliers $32.00-$1010.00

Similar articles

IF:13

Linagliptin: in type 2 diabetes mellitus.

Drugs Lesley J Scott,etc Published: 26 March 2011
IF:13

Dapagliflozin: a review of its use in type 2 diabetes mellitus.

Drugs Greg L Plosker,etc Published: 3 December 2012
土默特左旗| 正镶白旗| 秭归县| 石首市| 武义县| 香港| 平罗县| 瑞安市| 措勤县| 九龙城区| 揭阳市| 商洛市| 苏尼特左旗| 区。| 科技| 宜兰县| 宁武县| 宝坻区| 阿巴嘎旗| 辉南县| 介休市| 白河县| 柳州市| 绍兴县| 宣武区| 蕉岭县| 顺义区| 永州市| 嘉荫县| 岐山县| 望奎县| 宜章县| 调兵山市| 凯里市| 沭阳县| 山西省| 泰宁县| 万源市| 乐东| 南安市| 新密市|