一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> International Journal of Molecular Sciences >>article
International Journal of Molecular Sciences

International Journal of Molecular Sciences

IF: 5.6
Download PDF

Anti-Tumor Effects of Sheep Umbilical Cord Mesenchymal Stem Cells on Melanoma Cells

Published:6 January 2025 DOI: 10.3390/ijms26010426 PMID: 39796281
Fengjiao Yue,?Yuqing Zhao,?Yiting Lv,?Songmei Li,?Weihai Wang,?Yajun Li,?Shujie Wang,?Chunsheng Wang

Abstract

Melanoma is among the most common malignancies and has recently exhibited increased resistance to treatments, resulting in a more aggressive disease course. Mesenchymal stem cells (MSCs) secrete cytokines both in vivo and in vitro, which regulate tumor cell signaling pathways and the tumor microenvironment, thereby influencing tumor progression. This study investigates the anti-melanogenesis effects of sheep umbilical cord mesenchymal stem cells (SUCMSCs) to assess their potential application in melanoma treatment. Our findings indicate that, in vitro, SUCMSCs reduce melanin content and tyrosinase activity, inhibit melanoma cell viability, proliferation, migration, and invasion, and promote melanoma cell apoptosis. Subsequent in vivo experiments confirmed that SUCMSCs effectively suppress tumor growth, and histological analysis via HE staining revealed notable differences. Additionally, transcriptome sequencing analysis indicated that the anti-tumor effects were primarily mediated through autophagy, apoptosis, and the TGF-β and NF-κB signaling pathways. The RT-qPCR validation results aligned with the transcriptome data. In summary, SUCMSCs exert anti-melanogenesis effects through the interaction of multiple signaling pathways and cytokines, demonstrating significant potential for melanoma treatment.

Similar articles

IF:7.7

Analysis on the involvement of phosphoglycerate mutase 1 in the aerobic glycolysis of melanoma cells

International Journal of Biological Macromolecules Qiang Wang, Zhongliang Lang,etc Published: 1 December 2024
岢岚县| 石河子市| 广德县| 伊春市| 樟树市| 青河县| 邓州市| 库尔勒市| 鲁山县| 佛山市| 大竹县| 逊克县| 西畴县| 措美县| 繁峙县| 江陵县| 遵化市| 庆阳市| 保靖县| 巧家县| 萨迦县| 中江县| 大连市| 周宁县| 定兴县| 始兴县| 英吉沙县| 平乐县| 兴国县| 江口县| 正镶白旗| 井陉县| 佛山市| 萨嘎县| 治县。| 深水埗区| 如东县| 肇庆市| 华安县| 个旧市| 出国|