一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> iScience >>article
iScience

iScience

IF: 4.6
Download PDF

GPX4 dependent ferroptosis sensitivity is a fitness trade-off for cell enlargement

Published:9 April 2025 DOI: 10.1016/j.isci.2025.112363
Kuan Yoow Chan , Yini Yu , Yidi Kong , Ling Cheng , Renzhi Yao , Phoebe Sha Yin Chair , Ping Wang , Rong Wang , Wan-Yang Sun , Rong-Rong He , Junxia Min , Fudi Wang , Mikael Bj?rklund

Abstract

Despite wide variation, each cell type has an optimal size. Maintaining optimal size is essential for cellular fitness and function but the biological basis for this remains elusive. Here, we performed fitness analysis involving genome-wide CRISPR-Cas9 knockout data from tens of human cell lines and identified that cell size influences the essentiality of genes related to mitochondria and membrane repair. These genes also included glutathione peroxidase 4 (GPX4), which safeguards membranes from oxidative damage and prevents ferroptosis—iron-dependent death. Growth beyond normal size, with or without cell-cycle arrest, increased lipid peroxidation, resulting in a ferroptosis-sensitive state. Proteomic analysis revealed cell-cycle-independent superscaling of endoplasmic reticulum, accumulation of iron, and lipidome remodeling. Even slight increases from normal cell size sensitized proliferating cells to ferroptosis as evidenced by deep-learning-based single-cell analysis. Thus, lipid peroxidation may be a fitness trade-off that constrains cell enlargement and contributes to the establishment of an optimal cell size.

Substances (38)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Sulfasalazine 599-79-1 C18H14N4O5S 475 suppliers $7.00-$690.00
Sulfasalazine 599-79-1 C18H14N4O5S 475 suppliers $7.00-$690.00
Sulfasalazine 599-79-1 C18H14N4O5S 475 suppliers $7.00-$690.00
Sulfasalazine 599-79-1 C18H14N4O5S 475 suppliers $7.00-$690.00
Necrostatin-1 4311-88-0 C13H13N3OS 258 suppliers $12.00-$2008.00
Necrostatin-1 4311-88-0 C13H13N3OS 258 suppliers $12.00-$2008.00
Necrostatin-1 4311-88-0 C13H13N3OS 258 suppliers $12.00-$2008.00
Necrostatin-1 4311-88-0 C13H13N3OS 258 suppliers $12.00-$2008.00
Auranofin 34031-32-8 C20H34AuO9PS 197 suppliers $45.00-$2290.00
Auranofin 34031-32-8 C20H34AuO9PS 197 suppliers $45.00-$2290.00

Similar articles

IF:5.3

Etoposide induces cell death via mitochondrial-dependent actions of p53.

Cancer Cell International Sarwat Jamil, Irene Lam,etc Published: 7 August 2015
长治县| 读书| 右玉县| 盐池县| 松江区| 自治县| 高碑店市| 清流县| 南木林县| 荣昌县| 长汀县| 嘉义县| 昌平区| 西青区| 新巴尔虎左旗| 宝清县| 贵港市| 安义县| 龙海市| 康乐县| 启东市| 布尔津县| 萨迦县| 汾阳市| 芮城县| 广丰县| 华亭县| 巨野县| 苍山县| 广宁县| 张家川| 邢台县| 南投县| 舟曲县| 乐东| 延长县| 旬阳县| 英德市| 八宿县| 邹城市| 钦州市|