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ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA

Published:24 June 2025 DOI: 10.1016/j.celrep.2025.115851 PMID: 40516055
Huiyan Ji,?Wanwan Jiang,?Juan Zhang,?Mengdi Liu,?Danhua Su,?Jiaxin Lei,?Lingyi Li,?Ming Zheng,?Ting Liu,?Zhichun Liu,?Qinghua Cao,?Lin Xu,?Sidong Xiong,?Zhenke Wen

Abstract

T cells play a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE), yet the underlying molecular mechanisms governing their fate remain elusive. Here, we identify cytosolic mitochondrial DNA (mtDNA) as an intrinsic trigger for driving effector T cell differentiation in patients with SLE. Specifically, accumulated cytosolic mtDNA is sensed by ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), which enhances the transcription of GLUT1 and glycolysis in SLE T cells. This metabolic shift reduces lipogenesis and depletes free fatty acids (FFAs), impairing the N-myristylation and lysosomal localization of AMP-activated protein kinase (AMPK). Inactive AMPK fails to restrain mammalian target of rapamycin complex 1 (mTORC1), leading to its hyperactivation and driving the mal-differentiation of effector T cells. Consequently, interventions targeting ENPP1, glycolysis, AMPK, and mTORC1 effectively inhibit the generation of immunoglobulin (Ig)G anti-double-stranded DNA (dsDNA) and the progression of lupus nephritis in humanized SLE chimeras. Overall, our findings uncover an mtDNA-ENPP1-metabolic axis that governs effector T cell fate in autoimmunity.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea 941987-60-6 C17H17N3O 113 suppliers $9.79-$1872.00
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea 941987-60-6 C17H17N3O 113 suppliers $9.79-$1872.00
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea 941987-60-6 C17H17N3O 113 suppliers $9.79-$1872.00
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea 941987-60-6 C17H17N3O 113 suppliers $9.79-$1872.00

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