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Protective Effects of Pasireotide in LPS-Induced Acute Lung Injury

Published:22 June 2025 DOI: 10.3390/ph18070942 PMID: 40732232
Saikat Fakir,?Md Matiur Rahman Sarker,?Madan Sigdel,?Nektarios Barabutis

Abstract

Background/Objectives: Acute lung injury (ALI) is an inflammatory condition characterized by tissue barrier damage, which leads to vascular leakage, pulmonary edema, and compromised gas exchange. Lipopolysaccharides (LPS) are a component of Gram-negative bacteria, which trigger inflammation by Toll-like receptor 4 (TLR4) activation. Herein, we investigated the possibility that Pasireotide (PAS) exerts protective effects in an experimental model of ALI. Methods: C57BL/6 male mice received an intratracheal injection of saline or LPS, followed by PAS or vehicle treatment. Bronchoalveolar lavage fluid (BALF) was collected via tracheal catheterization, and Western blot analysis was used to detect protein expression variations. Results: Our results suggest that PAS treatment alleviates LPS-induced mouse lung injury and inflammation. JAK/STAT and MAPK activation levels in the inflamed lungs were suppressed due to PAS treatment, as well as BALF protein concentration. Additionally, PAS counteracted LPS-induced Grp94 protein reduction, suggesting the involvement of ATF6 in PAS-triggered barrier-protective effects. Grp94 is a downstream ATF6 target. Conclusions: Our data demonstrate that PAS protects mouse lungs against LPS in an experimental model of ALI.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Pasireotide Acetate 396091-76-2 C60H70N10O11 20 suppliers Inquiry
Pasireotide Acetate 396091-76-2 C60H70N10O11 20 suppliers Inquiry
Pasireotide Acetate 396091-76-2 C60H70N10O11 20 suppliers Inquiry
Pasireotide Acetate 396091-76-2 C60H70N10O11 20 suppliers Inquiry

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