Electroorganic synthesis of 6-aminonicotinic acid from 2-amino-5-chloropyridine
Published:19 May 2003
DOI: 10.1016/S0040-4039(03)00816-5
R. Ramesh Raju, S. Krishna Mohan, S. Jayarama Reddy
Abstract
A synthesis of 6-aminonicotinic acid by electrochemical hydrogenation of 5-chloro-2-nitropyridine and electrochemical carboxylation of 2-amino-5-chloropyridine at a cathode surface in the presence of sulphuric acid and carbon dioxide in a dimethylformamide (DMF) solution at an apparent current density of 10 mA/cm2 using an undivided cell with good yields is reported.
