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Tetrahedron Letters

Tetrahedron Letters

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Synthetic strategies for preparation of cyclen-based MRI contrast agents

Published:4 February 2015 DOI: 10.1016/j.tetlet.2014.12.087
Nevenka Caki?, Serhat Gündüz, Rathikrishnan Rengarasu, Goran Angelovski

Abstract

Cyclen-based macrocyclic ligands have an essential role in the development of contrast agents for magnetic resonance imaging (MRI). A prevailing need for preparation of multifunctional probes triggered a number of attempts to synthesize and derivatize ligands which efficiently chelate lanthanide ions and have advantageous MRI properties. This digest Letter summarizes the most common synthetic approaches for the preparation of macrocyclic ligands based on cyclen depending on the desired application.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Cyclen 294-90-6 C8H20N4 614 suppliers $5.00-$2055.90
Lanthanide Sesqui Sulfides 1 suppliers Inquiry

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