An efficient FeCl3-catalyzed amidation reaction of secondary benzylic and allylic alcohols with carboxamides or p-toluenesulfonamide

Published:28 January 2008 DOI: 10.1016/j.tetlet.2007.11.176

Umasish Jana, Sukhendu Maiti, Srijit Biswas

Abstract

A simple, inexpensive, environmentally friendly and high yielding amidation reaction of benzylic and allylic alcohols with primary amides using a catalytic amount of FeCl₃ (5?mol?%) is described. Direct substitution of various amides such as benzamide, sulfonamide, acetamide and acrylamide is reported, and this method also works on a large scale in high yield.