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ACS Sensors

ACS Sensors

IF: 8.2
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Construction of a TICT-AIE-Integrated Unimolecular Platform for Imaging Lipid Droplet–Mitochondrion Interactions in Live Cells and In Vivo

Published:19 December 2022 DOI: 10.1021/acssensors.2c01361 PMID: 36533530
Shu-Tang Zeng, Wen Shao, Ze-Yi Yu, Lan Fang, Gui-Xue Tang, Yu-Ying Fang, Shuo-Bin Chen, Zhi-Shu Huang, Jia-Heng Tan* and Xiu-Cai Chen*, 

Abstract

Inter-organelle interactions play a vital role in diverse biological processes. Thus, chemical tools are highly desirable for understanding the spatiotemporal dynamic interplay among organelles in live cells and in vivo. However, designing such tools is still a great challenge due to the lack of universal design strategies. To break this bottleneck, herein, a novel unimolecular platform integrating the twisted intramolecular charge transfer (TICT) and aggregation-induced emission (AIE) dual mechanisms was proposed. As a proof of concept, two organelles, lipid droplets (LDs) and mitochondria, were selected as models. Also, the first TICT-AIE integration molecule, BETA-1, was designed for simultaneous and dual-color imaging of LDs and mitochondria. BETA-1 can simultaneously target LDs and mitochondria due to its lipophilicity and cationic structure and emit cyan fluorescence in LDs and red fluorescence in mitochondria. Using BETA-1, for the first time, we obtained long-term tracking of dynamic LD–mitochondrion interactions and identified several impressive types of dynamic interactions between these two organelles. More importantly, the increase in LD–mitochondrion interactions during ferroptosis was revealed with BETA-1, suggesting that intervening in the LD–mitochondrion interactions may modulate this cell death. BETA-1 was also successfully applied for in vivo imaging of LD–mitochondrion interactions in C. elegans. This study not only provides an effective tool for uncovering LD–mitochondrion interactions and deciphering related biological processes but also sheds light on the design of new probes with an integrated TICT-AIE mechanism for imaging of inter-organelle interactions.

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Procduct Name CAS Molecular Formula Supplier Price
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2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone 571203-78-6 C30H31ClN4O4 284 suppliers $16.00-$2691.10
2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone 571203-78-6 C30H31ClN4O4 284 suppliers $16.00-$2691.10
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