一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy >>article

Synthesis and characterization of transition metal 2,6-pyridinedicarboxylic acid derivatives, interactions of Cu(II) and Ni(II) complexes with DNA in vitro

Published:1 March 2009 DOI: 10.1016/j.saa.2008.10.001 PMID: 19046927
Sadaf Khan , Shahab A.A. Nami , K.S. Siddiqi , Eram Husain , Imrana Naseem

Abstract

Mononuclear complexes M(L)Cl2 where M?=?Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) and (L?=?N,N-diethylpiperazinyl,2,6-pyridinedicarboxylate), have been synthesized and characterized by elemental analysis, FT-IR, 1H NMR spectroscopy, UV–vis, magnetic moment, TGA/DSC, cyclic voltammetry and conductivity measurement data. The spectral data suggests that the dipicolinic acid acts as a bidentate ligand and is coordinated to the metal ion through the carboxylate oxygen. The cyclic voltammogram for Cu(L)Cl2 complex was found to display two reversible Cu(II)/Cu(I) and Cu(II)/Cu(III) redox couple. The ligand exhibits a two-step thermolytic pattern while the complexes decompose in three stages respectively. An octahedral geometry has been proposed for both the complexes. The investigation of the interaction of the complexes with calf thymus DNA has been performed with absorption spectroscopy and fluorescence quenching experiments, which showed that the complexes are avid binders of calf thymus DNA. Also the interaction of the Cu(II) and Ni(II) complexes with plasmid DNA (pUC 19) was studied using agarose gel electrophoresis. The results revealed that these complexes can act as effective DNA cleaving agents resulting in the nicked form of DNA (pUC 19) under physiological conditions. The gel was run both in the absence and presence of an oxidizing agent (H2O2). The ligand and its complexes have also been screened against microbes in order to study their antibacterial action. The results revealed that the Cu(II) complex has activity comparable with the reference drugs gentamycin and flucanzole.

Substances (9)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Cuprous oxide 1317-39-1 Cu2O 482 suppliers $5.00-$1134.44
Gentamicin 1403-66-3 C60H123N15O21 170 suppliers Inquiry
meso-Tetrakis(4-chlorophenyl)porphyrin-Co(II) 55915-17-8 C44H24Cl4CoN4 48 suppliers Inquiry
MANGANESE(II) CARBONATE HYDRATE 34156-69-9 CH4MnO4 36 suppliers $16.80-$498.00
TCPP-Ni(2+) 41699-92-7 C48H25N4NiO8(-3) 30 suppliers Inquiry
GADOLINIUM NITRIDE 25764-15-2 GdN 24 suppliers $36.00-$145.00
5,10,15,20-TETRAKIS(4-SULFONATOPHENYL)-21H,23H-PORPHINE COPPER(II) 56047-84-8 C44H25CuN4O12S4(-3) 16 suppliers Inquiry
Iron (II) citrate,powder.approx.22% Fe(II).99% C12H10Fe3O14 6 suppliers Inquiry
Flucanzole 1 suppliers Inquiry

Similar articles

IF:4.3

Spectroscopic and biological approach of Ni(II) and Cu(II) complexes of 2-pyridinecarboxaldehyde thiosemicarbazone

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Sulekh Chandra , Smriti Raizada ,etc Published: 1 March 2008
IF:2.4

N,N-Dimethylethylenediamine in direct and direct template syntheses of Cu(II)/Cr(III) complexes

Polyhedron Vitalina M. Nikitina , Oksana V. Nesterova ,etc Published: 12 May 2009
泽普县| 西安市| 荆州市| 西宁市| 太原市| 揭东县| 黄浦区| 新疆| 慈利县| 五大连池市| 双桥区| 崇文区| 广安市| 基隆市| 华坪县| 山丹县| 寻乌县| 屏山县| 绥德县| 河北区| 胶州市| 闽侯县| 赤壁市| 天等县| 杂多县| 松潘县| 韶关市| 连江县| 合肥市| 台湾省| 安仁县| 穆棱市| 昌平区| 广昌县| 三都| 连城县| 新竹市| 攀枝花市| 连州市| 灵丘县| 含山县|