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Isolation, Structural Elucidation, and ?-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum

Published:8 June 2018 DOI: 10.3390/molecules23061391 PMID: 29890656
Xian-Qiang Chen, Li-Gen Lin, Jing Zhao, Ling-Xiao Chen, Yu-Ping Tang, De-Lun Luo, Shao-Ping Li

Abstract

Ganoderma resinaceum has been used as an ethnomedicine for lowering blood sugar. To clarify the bioactive chemical constituents contributing to lower blood sugar, chemical investigation on the fruiting bodies of Ganoderma resinaceum was conducted by chromatographic techniques, and led to the isolation of 14 compounds. Their structures were elucidated as triterpenoid lactones (1?4 and 8) and ganoderma acids (5?7 and 9?14) based on the analysis of extensive spectroscopy (mass spectrometry (MS), nuclear magnetic resonance (NMR), infrared (IR), and ultraviolet (UV)) and comparison with literature data. Compounds 3, 5, 6, and 9?14 were evaluated for α-glucosidase inhibitory activity. Compounds 1?7 are new compounds. Compounds 1?4 and 8 were characteristic of an oxaspirolactone moiety, consisting of a five-membered ether ring, a five-membered lactone ring, and a characteristic C-23 spiro carbon. It is rare for natural products that such an oxaspirolactone moiety occurred in the lanostane-type triterpenoids. Compounds 5?7 and 9?14 may be important intermediates of the biosynthetic pathways of 1?4 and 8. Compounds 1 and 2 showed more potent inhibitory activity against α-glucosidase compared with the positive control drug acarbose with IC50 value of 0.75 ± 0.018 mM and 1.64 ± 0.022 mM, respectively.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Acarbose 56180-94-0 C25H43NO18 746 suppliers $6.00-$2245.70
Acarbose 56180-94-0 C25H43NO18 746 suppliers $6.00-$2245.70
Acarbose 56180-94-0 C25H43NO18 746 suppliers $6.00-$2245.70
Acarbose 56180-94-0 C25H43NO18 746 suppliers $6.00-$2245.70
Acarbose 56180-94-0 - Inquiry
Acarbose 56180-94-0 - Inquiry
Acarbose 56180-94-0 - Inquiry
Acarbose 56180-94-0 - Inquiry

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