一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Nature Communications >>article
Nature Communications

Nature Communications

IF: 14.7
Download PDF

A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development

Published:23 April 2019 DOI: 10.1038/s41467-019-09839-x PMID: 31015473
Yuanyuan Shi, Xiaoqing Hu, Jin Cheng, Xin Zhang, Fengyuan Zhao, Weili Shi, Bo Ren, Huilei Yu, Peng Yang, Zong Li, Qiang Liu, Zhenlong Liu, Xiaoning Duan, Xin Fu, Jiying Zhang, Jianquan Wang, Yingfang Ao

Abstract

Degradation of extracellular matrix (ECM) underlies loss of cartilage tissue in osteoarthritis, a common disease for which no effective disease-modifying therapy currently exists. Here we describe BNTA, a small molecule with ECM modulatory properties. BNTA promotes generation of ECM components in cultured chondrocytes isolated from individuals with osteoarthritis. In human osteoarthritic cartilage explants, BNTA treatment stimulates expression of ECM components while suppressing inflammatory mediators. Intra-articular injection of BNTA delays the disease progression in a trauma-induced rat model of osteoarthritis. Furthermore, we identify superoxide dismutase 3 (SOD3) as a mediator of BNTA activity. BNTA induces SOD3 expression and superoxide anion elimination in osteoarthritic chondrocyte culture, and ectopic SOD3 expression recapitulates the effect of BNTA on ECM biosynthesis. These observations identify SOD3 as a relevant drug target, and BNTA as a potential therapeutic agent in osteoarthritis.

Similar articles

IF:5.3

HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS‐induced acute kidney injury

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Lili Huang, Yuanyuan Wu,etc Published: 25 November 2024
IF:4.3

Dihydromyricetin inhibits cell proliferation, migration, invasion and promotes apoptosis via regulating miR-21 in Human Cholangiocarcinoma Cells.

ACS Applied Electronic Materials Lei Chen, Zhou-Sheng Yang,etc Published: 29 July 2020
卓资县| 疏附县| 仁化县| 招远市| 涡阳县| 彝良县| 黑河市| 榆中县| 安陆市| 灌阳县| 沂南县| 舞钢市| 兴海县| 西乌| 定陶县| 清新县| 本溪| 吴旗县| 岫岩| 隆昌县| 涟源市| 红安县| 古蔺县| 青阳县| 高雄县| 琼结县| 渝北区| 安西县| 合作市| 龙门县| 玉田县| 两当县| 额尔古纳市| 武安市| 于都县| 沙河市| 洞口县| 临泽县| 安福县| 清河县| 射洪县|