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Brain, Behavior, and Immunity

Brain, Behavior, and Immunity

IF: 8.8
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Spinal microglial activation promotes perioperative social defeat stress-induced prolonged postoperative pain in a sex-dependent manner

Published:1 February 2022 DOI: 10.1016/j.bbi.2021.11.010 PMID: 34808295
Wang Wang , Wei-Zhen Liu , Zi-Liang Wang , Dong-Xiao Duan , Xue-Yun Wang , Shi-Jin Liu , Zhi-Ju Wang , Guo-Gang Xing , Ying Xing

Abstract

Prolonged postsurgical pain, which is associated with multiple risk factors in the perioperative stage, is a common medical and social problem worldwide. Suitable animal models should be established to elucidate the mechanisms underlying the perioperative prolonged postsurgical pain. In this study, standard and modified social defeat stress mice models, including chronic social defeat stress (CSDS), chronic nondiscriminatory social defeat stress (CNSDS) and vicarious social defeat stress (VSDS), were applied to explore the effect of perioperative social defeat stress on postsurgical pain in male and female mice. Our results showed that exposure to preoperative CSDS could induce prolonged postsurgical pain in defeated mice regardless of susceptibility or resilience differentiated by the social interaction test. Similar prolongation of incision-induced mechanical hypersensitivity was also observed in both sexes upon exposing to CNSDS or VSDS in the preoperative period. Moreover, we found that using the modified CNSDS or VSDS models at different recovery stages after surgery could still promote abnormal pain without sex differences. Further studies revealed the key role of spinal microglial activation in the stress-induced transition from acute to prolonged postoperative pain in male but not female mice. Together, these data indicate that perioperative social defeat stress is a vital risk factor for developing prolonged postoperative pain in both sexes, but the promotion of stress-induced prolonged postoperative pain by spinal microglial activation is sexually dimorphic in mice.

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Procduct Name CAS Molecular Formula Supplier Price
Minocycline hydrochloride 13614-98-7 C23H28ClN3O7 658 suppliers $5.00-$4026.00
Minocycline hydrochloride 13614-98-7 C23H28ClN3O7 658 suppliers $5.00-$4026.00
Minocycline hydrochloride 13614-98-7 C23H28ClN3O7 658 suppliers $5.00-$4026.00
Minocycline hydrochloride 13614-98-7 C23H28ClN3O7 658 suppliers $5.00-$4026.00
Minocycillin 13614-98-7 - Inquiry
Minocycillin 13614-98-7 - Inquiry

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