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Water Extract of Fritillariae thunbergii Bulbus Inhibits RANKL-Mediated Osteoclastogenesis and Ovariectomy-Induced Trabecular Bone Loss

Published:28 December 2021 DOI: 10.3390/molecules27010169 PMID: 35011398
Ki-Shuk Shim, Dong-Ryun Gu, Youn-Hwan Hwang, Hyun Yang, Jin-Ah Ryuk, Hyunil Ha

Abstract

Fritillariae thunbergii bulbus has been widely used to treat symptoms of coughs and airway congestion in the chest due to pathological colds and damp phlegm in traditional Chinese medicine. Despite its long history of traditional use, its pharmacological activities on osteoclastogenesis and osteoporosis have not been evaluated. This study investigated the effects of the water extract of Fritillariae thunbergii bulbus (WEFT) on osteoclast differentiation in bone marrow-derived macrophage cells and on ovariectomy (OVX)-induced osteoporosis in mice. We found that WEFT significantly inhibited osteoclastogenesis by downregulating the receptor activator of the NF-κB ligand (RANKL) signaling-induced nuclear factor of activated T-cells cytoplasmic 1 (NFATc1) expression. In an OVX-induced osteoporosis model, WEFT significantly prevented the OVX-induced trabecular loss of femurs, accompanied by a reduction in fat accumulation in the bone marrow and liver. In addition, WEFT significantly prevented weight gain and gonadal fat gain without recovering uterine atrophy. Using ultrahigh-performance liquid chromatography-tandem mass spectrometry, seven alkaloids (peimisine glucoside, yibeissine, peiminoside, sipeimine-glucoside, peimisine, peimine, and peiminine) were identified in WEFT. The results of this study suggest that WEFT can be a potential pharmacological candidate to reduce menopausal osteoporosis and menopause-related symptoms, such as fat accumulation.

Substances (16)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Peiminine 18059-10-4 C27H43NO3 293 suppliers $38.00-$1443.17
Peiminine 18059-10-4 C27H43NO3 293 suppliers $38.00-$1443.17
Peiminine 18059-10-4 C27H43NO3 293 suppliers $38.00-$1443.17
Peiminine 18059-10-4 C27H43NO3 293 suppliers $38.00-$1443.17
peimisine 19773-24-1 C27H41NO3 182 suppliers $49.00-$8670.00
peimisine 19773-24-1 C27H41NO3 182 suppliers $49.00-$8670.00
peimisine 19773-24-1 C27H41NO3 182 suppliers $49.00-$8670.00
peimisine 19773-24-1 C27H41NO3 182 suppliers $49.00-$8670.00
SipeiMine-3β-D-glucoside 32685-93-1 C33H53NO8 168 suppliers Inquiry
SipeiMine-3β-D-glucoside 32685-93-1 C33H53NO8 168 suppliers Inquiry

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