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British Journal of Dermatology

British Journal of Dermatology

IF: 11
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Fusidic acid in dermatology

Published:12 January 2010 DOI: 10.1046/j.1365-2133.1998.1390s3037.x PMID: 9990411
Wilkinson

Abstract

Fusidic acid is an antibiotic that belongs to a group of its own, the fusidanes. The molecule has a steroid-like structure but does not possess any steroid activity. The structure is thought to be responsible for the steroid-like high penetration, and for the fact that no cross-resistance or cross-allergy has been seen with other antibiotics in routine clinical use. The anti-microbial activity of fusidic acid is specifically aimed at the most common skin pathogens, including Staphylococcus aureus, towards which it is one of the most potent antibiotics. The place of fusidic acid in dermatology is in the treatment of mild to moderately severe skin and soft-tissue infections, e.g. impetigo, folicullitis, erythrasma, furunculosis, abscesses and infected traumatic wounds, whereas it is of less use in conditions such as hidradenitis suppurativa, chronic leg ulcers, burns and pressure sores. The topical combinations of fusidic acid with either betamethasone or hydrocortisone are extremely useful in the treatment of atopic dermatitis/eczema whenever staphylococcal/secondary infection is suspected, and in more persistent cases of eczema where staphylococcal superantigen may be playing an important exacerbating role.

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Procduct Name CAS Molecular Formula Supplier Price
Hydrocortisone 50-23-7 C21H30O5 946 suppliers $25.00-$15100.00
Betamethasone 378-44-9 C22H29FO5 723 suppliers $39.00-$1504.50
Fusidic Acid 6990-06-3 C31H48O6 402 suppliers $5.00-$2333.10
ALPHA-HEMOLYSIN 12616-52-3 13 suppliers Inquiry

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