一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Viruses-Basel >>article
Viruses-Basel

Viruses-Basel

IF: 3.5
Download PDF

Encephalomyocarditis Virus 2A Protein Inhibited Apoptosis by Interaction with Annexin A2 through JNK/c-Jun Pathway

Published:1 February 2022 DOI: 10.3390/v14020359
Ruochan Han,?L. Liang,?Tong Qin,?S. Xiao,?Ruiying Liang

Abstract

Encephalomyocarditis virus can cause myocarditis and encephalitis in pigs and other mammals, thus posing a potential threat to public health safety. The 2A protein is an important virulence factor of EMCV. Previous studies have shown that the 2A protein may be related to the inhibition of apoptosis by virus, but its specific molecular mechanism is not clear. In this study, the 2A protein was expressed in Escherichia coli in order to find interacting cell proteins. A pull down assay, coupled with mass spectrometry, revealed that the 2A protein possibly interacted with annexin A2. Co-immunoprecipitation assays and confocal imaging analysis further demonstrated that the 2A protein interacted with annexin A2 in cells. In reducing the expression of annexin A2 by siRNA, the ability of the 2A protein to inhibit apoptosis was weakened and the proliferation of EMCV was slowed down. These results suggest that annexin A2 is closely related to the inhibition of apoptosis by 2A. Furthermore, both RT-PCR and western blot results showed that the 2A protein requires annexin A2 interaction to inhibit apoptosis via JNK/c-Jun pathway. Taken together, our data indicate that the 2A protein inhibits apoptosis by interacting with annexin A2 via the JNK/c-Jun pathway. These findings provide insight into the molecular pathogenesis underlying EMCV infection.

Substances (5)

Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1) 66592-89-0 C5H10ClN3S 94 suppliers $9.00-$3187.00
CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1) 66592-89-0 C5H10ClN3S 94 suppliers $9.00-$3187.00
CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1) 66592-89-0 C5H10ClN3S 94 suppliers $9.00-$3187.00
CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1) 66592-89-0 C5H10ClN3S 94 suppliers $9.00-$3187.00

Similar articles

IF:4.6

Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of the Hepatitis C Virus NS5B Polymerase Inhibitor Sofosbuvir.

Clinical Pharmacokinetics Brian J Kirby, William T Symonds,etc Published: 1 July 2015
IF:3.3

MOTS-c relieves hepatocellular carcinoma resistance to TRAIL-induced apoptosis under hypoxic conditions by activating MEF2A

Experimental cell research Haiying Shen, Junjie Nie,etc Published: 22 November 2024
利津县| 丰顺县| 枣阳市| 兴义市| 彰化市| 建水县| 四川省| 江津市| 沾化县| 景洪市| 黑龙江省| 绩溪县| 闸北区| 同仁县| 清镇市| 平江县| 马公市| 灵川县| 张北县| 孟州市| 麻阳| 兴国县| 黄龙县| 佛山市| 望都县| 田东县| 镇坪县| 枣强县| 三门县| 旬阳县| 东光县| 杭锦后旗| 紫金县| 兰州市| 巩留县| 淮安市| 苏州市| 长兴县| 永修县| 芜湖县| 瑞安市|