一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Polymers >>article
Polymers

Polymers

IF: 4.7
Download PDF

Design and Fabrication of Nanofibrous Dura Mater with Antifibrosis and Neuroprotection Effects on SH-SY5Y Cells

Published:1 May 2022 DOI: 10.3390/polym14091882
Zhi-wei Zhao,?Tong Wu,?Yu Cui,?Rui Zhao,?Qi Wan,?Rui Xu

Abstract

The development and treatment of some diseases, such as large-area cerebral infarction, cerebral hemorrhage, brain tumor, and craniocerebral trauma, which may involve the injury of the dura mater, elicit the need to repair this membrane by dural grafts. However, common dural grafts tend to result in dural adhesions and scar tissue and have no further neuroprotective effects. In order to reduce or avoid the complications of dural repair, we used PLGA, tetramethylpyrazine, and chitosan as raw materials to prepare a nanofibrous dura mater (NDM) with excellent biocompatibility and adequate mechanical characteristics, which can play a neuroprotective role and have an antifibrotic effect. We fabricated PLGA NDM by electrospinning, and then chitosan was grafted on the nanofibrous dura mater by the EDC-NHS cross-linking method to obtain PLGA/CS NDM. Then, we also prepared PLGA/TMP/CS NDM by coaxial electrospinning. Our study shows that the PLGA/TMP/CS NDM can inhibit the excessive proliferation of fibroblasts, as well as provide a sustained protective effect on the SH-SY5Y cells treated with oxygen–glucose deprivation/reperfusion (OGD/R). In conclusion, our study may provide a new alternative to dural grafts in undesirable cases of dural injuries.

Similar articles

IF:4.2

Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells

European journal of pharmacology Li Zhang , Huixin Yu ,etc Published: 14 June 2007
IF:3.8

4-Methylumbelliferone enhances the effects of chemotherapy on both temozolomide-sensitive and resistant glioblastoma cells.

Scientific Reports Matías A Pibuel,?Daniela Poodts,etc Published: 8 June 2023
IF:3.4

Interaction of methylenedioxyphenyl (1,3-benzodioxole) compounds with enzymes and their effects on mammals.

Drug Metabolism Reviews E Hodgson, R M Philpot,etc Published: 1 January 1974
三河市| 巨鹿县| 晋宁县| 化德县| 榆林市| 四会市| 石林| 马龙县| 西贡区| 屏南县| 凤庆县| 秦安县| 班戈县| 马公市| 本溪| 杭锦旗| 定州市| 临澧县| 华容县| 新营市| 大埔区| 桦甸市| 青海省| 宝清县| 星座| 体育| 满城县| 西充县| 黑龙江省| 什邡市| 临潭县| 松江区| 长武县| 万盛区| 巴林左旗| 慈利县| 华宁县| 沈阳市| 卫辉市| 青龙| 秦安县|