一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cell reports >>article
Cell reports

Cell reports

IF: 7.5
Download PDF

Targeting VCP potentiates immune checkpoint therapy for colorectal cancer.

Published:28 November 2023 DOI: 10.1016/j.celrep.2023.113318 PMID: 37865914
Fang Wang,?Qi Qi,?Baifu Qin,?Yiwei Wang,?Youwei Huang,?Qing Li,?Xi Shen,?Xiangyu Wang,?Shangqi Yang,?Guopeng Pan,?Jiahong Chen,?Zixi Qin,?Xueqin Chen,?Yuqing Yang,?Yuequan Zeng,?Jun Liu,?Yuqin Li,?Ying Li,?Zexiong Cheng,?Xi Lin,?Fan Xing,?Yubo Zhang,?Guocai Wang,?Kai Li,?Zhenyou Jiang,?Haipeng Zhang

Abstract

Immune checkpoint blockade therapies are still ineffective for most patients with colorectal cancer (CRC). Immunogenic cell death (ICD) enables the release of key immunostimulatory signals to drive efficient anti-tumor immunity, which could be used to potentiate the effects of immune checkpoint inhibitors. Here, we showed that inhibition of valosin-containing protein (VCP) elicits ICD in CRC. Meanwhile, VCP inhibitor upregulates PD-L1 expression and compromises anti-tumor immunity in?vivo. Mechanistically, VCP transcriptionally regulates PD-L1 expression in a JAK1-dependent manner. Combining VCP inhibitor with anti-PD1 remodels tumor immune microenvironment and reduces tumor growth in mouse models of CRC. Addition of oncolytic virus further augments the therapeutic activity of the combination regimen. Our study shows the molecular mechanism for regulating PD-L1 expression by VCP and suggests that inhibition of VCP has the potential to increase the efficacy of immunotherapy in CRC.

Substances (1)

Related products
Procduct Name CAS Molecular Formula Supplier Price
(2,4-DICHLOROPHENYL)-METHANESULFONYL CHLORIDE 88691-50-3 C7H5Cl3O2S 60 suppliers $36.00-$1096.00

Similar articles

IF:1.8

Differential functionality of fluoropyrimidine nucleosides for safe cancer therapy.

Anti-Cancer Drugs Tim Holzinger,?Julia Frei,etc Published: 1 November 2024
IF:5.4

Sodium butyrate in both prevention and supportive treatment of colorectal cancer.

ACS Applied Energy Materials Karolina Ka?mierczak-Siedlecka, Luigi Marano,etc Published: 26 October 2022
石屏县| 陈巴尔虎旗| 繁昌县| 临泉县| 天全县| 瓮安县| 武功县| 民乐县| 丹巴县| 德安县| 喀喇沁旗| 镇沅| 丽江市| 赤水市| 绍兴县| 南通市| 南华县| 磐安县| 财经| 西峡县| 新巴尔虎右旗| 和龙市| 永康市| 钟山县| 通道| 宜黄县| 志丹县| 青州市| 成武县| 攀枝花市| 栾城县| 乌拉特后旗| 昌吉市| 陇西县| 仁布县| 竹北市| 于田县| 彭州市| 莲花县| 古田县| 哈尔滨市|