一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> The Journal of Organic Chemistry >>article
The Journal of Organic Chemistry

The Journal of Organic Chemistry

IF: 3.3
Download PDF

Versatile Acylation of N-Nucleophiles Using a New Polymer-Supported 1-Hydroxybenzotriazole Derivative

Published:18 April 1997 DOI: 10.1021/jo961761g PMID: 11671600
Iuliana E. Pop, Beno?t P. Déprez, André L. Tartar

Abstract

The synthesis of a new polymer-supported coupling reagent derived from 1-hydroxybenzotriazole is described. An aminomethylated polystyrene was functionalized by reaction with 3-nitro-4-chlorobenzenesulfonyl chloride (2) followed by treatement with hydrazine hydrate, to give the polymeric N-benzyl-1-hydroxybenzotriazole-6-sulfonamide (4).The polymeric reagent 4 was shown to be highly efficient for the synthesis of amides. The efficiency of 4 could be attributed to its high acidity, conferred by the sulfonyl moiety. The procedure for amide synthesis involves the formation of an activated ester on the derivatized polymer followed, in a second step, by treatment with an amine to generate the amide in solution. Simple filtration allows the separation of the product from the polymeric reagent which in this case plays the role of leaving group. An optimization study of this two-step procedure was performed. As amides are obtained in solution free of reaction byproducts, this method can be used in an automated procedure to recover them directly into a 96 well plate, ready to be used in high throughput screening assays. Thus 4 was shown to be particularly suitable for the high throughput parallel synthesis of amides libraries.

Synthesis

3-Chlorobenzonitrile
tert-Butanol
3-Chloro-N-(1,1-dimethylethyl)benzamide

Substances (4)

Related products
Procduct Name CAS Molecular Formula Supplier Price
1-Hydroxybenzotriazole 2592-95-2 C6H5N3O 838 suppliers $14.14-$693.00
4-Chlorobenzenesulfonyl chloride 98-60-2 C6H4Cl2O2S 404 suppliers $5.00-$808.96
4-Chloro-3-nitrobenzenesulfonyl chloride 97-08-5 C6H3Cl2NO4S 254 suppliers $8.00-$1077.34
4-CHLOROBENZENESULFONYL CHLORIDE 48-60-2 C6H4Cl2O2S 3 suppliers Inquiry

Similar articles

IF:2.5

N,N-diethylhydroxylamine: A new electron donor to photosystem II

Biochemical and biophysical research communications S.C. Sabat, T.Sudhakar Babu,etc Published: 16 September 1991
IF:4.1

Degradation of nonphenolic lignin by the laccase/1-hydroxybenzotriazole system

Journal of biotechnology Ewald Srebotnik , Kenneth E Hammel,etc Published: 25 August 2000
IF:7.5

New Diglyme-based Gel Polymer Electrolytes for Na-based Energy Storage Devices

ChemSusChem Dr. Binson Babu, Dr. Marcel Enke,etc Published: 2 September 2021
靖边县| 玉林市| 石门县| 乐昌市| 项城市| 龙江县| 当涂县| 仙居县| 陆河县| 丰原市| 金华市| 林州市| 信宜市| 泗阳县| 阳江市| 瑞安市| 牡丹江市| 张家口市| 巴彦县| 屏边| 中卫市| 合川市| 靖西县| 杨浦区| 金阳县| 徐州市| 营山县| 舟山市| 雅安市| 伊金霍洛旗| 建湖县| 康保县| 湘乡市| 普陀区| 夏津县| 庆云县| 娄烦县| 门头沟区| 淮南市| 丹江口市| 垣曲县|