一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Phytochemistry >>article
Phytochemistry

Phytochemistry

IF: 3.2
Download PDF

Anti-inflammatory lanostane triterpenoids with rearranged spirobi[indene] scaffold and their biogenetically related analogues from Euphorbia maculata

Published:1 July 2023 DOI: 10.1016/j.phytochem.2023.113682 PMID: 37084863
Ru-Feng Xia , Jun-Cheng Su , Jun Yu , Hong-Jing Zha , Jia-Le Wu , Xiao-Na Fu , Qin Cai , Luo-Sheng Wan

Abstract

Phytochemical investigations on the ethanol extract of the whole plant of Euphorbia maculata Linn. Resulted in the identification of 16 lanostane-related triterpenoids, including 11 undescribed ones, namely spiromaculatols A–C (13) and euphomaculatoids A–H (411). The structural determinations of the previously undescribed ones (111) were elucidated based on the interpretation of comprehensive spectroscopic data, quantum chemical calculation, as well as X-ray crystallographic experiments. Spiromaculatols A–C (13) possess a rare spirobi [indane] skeleton, which was biosynthetically derived from the 7 (8?→?9)-abeo bond migration of lanostane precursors. The biological activity of compounds 13, 5, 7, and 1213 displayed inhibitory effect on the release of NO in an LPS-activated RAW264.7?cells model. Molecular mechanism study indicated that the most potent spiromaculatol C (3) can reduce the nuclear translocation of NF-κB p65 and decrease the transcriptional expressions of its downstream pro-inflammatory mediators.

Similar articles

IF:3.2

Targeted isolation of lignans and triterpenoids from kadsura coccinea by molecular networking and anti-RA-FLS activity

Phytochemistry Shi-qi Liu, Qing-ling Xie,etc Published: 27 November 2024
IF:6.9

Assessment of the anti-angiogenic, anti-inflammatory and antinociceptive properties of ethyl vanillin

Archives of Pharmacal Research Hyun-Joo Jung, Yun Seon Song,etc Published: 2 May 2010
IF:4.9

Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug

Expert opinion on investigational drugs D. Agrawal,etc Published: 1 March 2001
温州市| 阿图什市| 广丰县| 卢湾区| 山东省| 阿图什市| 如皋市| 南漳县| 新昌县| 东乌珠穆沁旗| 巩义市| 寻乌县| 潞城市| 格尔木市| 宜丰县| 大荔县| 海伦市| 长武县| 沾化县| 弥渡县| 交城县| 紫云| 昭平县| 景洪市| 哈密市| 高邑县| 柞水县| 尼木县| 民勤县| 利辛县| 漠河县| 普陀区| 深州市| 格尔木市| 来凤县| 凤阳县| 钟祥市| 西乌| 义乌市| 南丹县| 民丰县|