一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> EMBO Reports >>article
EMBO Reports

EMBO Reports

IF: 6.2
Download PDF

Loss of renal tubular G9a benefits acute kidney injury by lowering focal lipid accumulation via?CES1

Published:5 June 2023 DOI: 10.15252/embr.202256128 PMID: 37042626
Dong Yang,?Yu Fan,?Mingrui Xiong,?Yuchen Chen,?Yihao Zhou,?Xikai Liu,?Yangmian Yuan,?Qing Wang,?Yu Zhang,?Robert B Petersen,?Hua Su,?Junqiu Yue,?Chun Zhang,?Hong Chen,?Kun Huang,?Ling Zheng

Abstract

Surgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. Lipid accumulation is evident following AKI in renal tubules although the mechanisms and pathological effects are unclear. Here, we report that Ehmt2-encoded histone methyltransferase G9a is upregulated in patients and mouse kidneys after AKI. Renal tubular specific knockout of G9a (Ehmt2Ksp ) or pharmacological inhibition of G9a alleviates lipid accumulation associated with AKI. Mechanistically, G9a suppresses transcription of the lipolytic enzyme Ces1; moreover, G9a and farnesoid X receptor (FXR) competitively bind to the same promoter regions of Ces1. Ces1 is consistently observed to be downregulated in the kidney of AKI patients. Pharmacological inhibition of Ces1 increases lipid accumulation, exacerbates renal I/R-injury and eliminates the beneficial effects on AKI observed in Ehmt2Ksp mice. Furthermore, lipid-lowering atorvastatin and an FXR agonist alleviate AKI by activating Ces1 and reducing renal lipid accumulation. Together, our results reveal a G9a/FXR-Ces1 axis that affects the AKI outcome via regulating renal lipid accumulation.

Substances (22)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Tween 80 9005-65-6 C24H44O6 1055 suppliers $15.00-$2720.00
Tween 80 9005-65-6 C24H44O6 1055 suppliers $15.00-$2720.00
Tween 80 9005-65-6 C24H44O6 1055 suppliers $15.00-$2720.00
Tween 80 9005-65-6 C24H44O6 1055 suppliers $15.00-$2720.00
Cisplatin 15663-27-1 Cl2H6N2Pt 922 suppliers $17.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 922 suppliers $17.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 922 suppliers $17.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 922 suppliers $17.00-$7570.00
Atorvastatin 134523-00-5 C33H35FN2O5 289 suppliers $8.00-$1189.65
Atorvastatin 134523-00-5 C33H35FN2O5 289 suppliers $8.00-$1189.65

Similar articles

IF:4.4

ACVR1 mediates renal tubular EMT in kidney fibrosis via AKT activation

Cellular signalling Tianli Yu, Zhangyu Mai,etc Published: 23 November 2024
IF:5.3

HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS‐induced acute kidney injury

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Lili Huang, Yuanyuan Wu,etc Published: 25 November 2024
IF:14.3

Tubular MYDGF Slows Progression of Chronic Kidney Disease by Maintaining Mitochondrial Homeostasis

Advanced Science Xiaohan Liu, Yang Zhang,etc Published: 26 November 2024
德清县| 安徽省| 马龙县| 凉城县| 宣城市| 奉新县| 邯郸县| 丰镇市| 金乡县| 宝兴县| 东源县| 峨眉山市| 清镇市| 新巴尔虎左旗| 大埔县| 山西省| 留坝县| 吉安市| 咸丰县| 竹北市| 藁城市| 繁峙县| 高淳县| 大连市| 建湖县| 柯坪县| 平武县| 荆州市| 项城市| 江源县| 沛县| 家居| 大理市| 荆门市| 普洱| 乐山市| 嘉荫县| 大石桥市| 聂荣县| 姜堰市| 阳信县|