一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Bioactive Materials >>article
Bioactive Materials

Bioactive Materials

IF: 18
Download PDF

Embryonic stem cell-derived extracellular vesicles rejuvenate senescent cells and antagonize aging in mice

Published:1 July 2023 DOI: PMID: 37449253
Lu Yu , Hang Wen , Chang Liu , Chen Wang , Huaxin Yu , Kaiyue Zhang , Qingsheng Han , Yue Liu , Zhongchao Han , Zongjin Li , Na Liu

Abstract

Aging is a degenerative process that leads to tissue dysfunction and death. Embryonic stem cells (ESCs) have great therapeutic potential for age-related diseases due to their capacity for self-renewal and plasticity. However, the use of ESCs in clinical treatment is limited by immune rejection, tumourigenicity and ethical issues. ESC-derived extracellular vesicles (EVs) may provide therapeutic effects that are comparable to those of ESCs while avoiding unwanted effects. Here, we fully evaluate the role of ESC-EVs in rejuvenation in vitro and in vivo. Using RNA sequencing (RNA-Seq) and microRNA sequencing (miRNA-Seq) screening, we found that miR-15b-5p and miR-290a-5p were highly enriched in ESC-EVs, and induced rejuvenation by silencing the Ccn2-mediated AKT/mTOR pathway. These results demonstrate that miR-15b-5p and miR-290a-5p function as potent activators of rejuvenation mediated by ESC-EVs. The rejuvenating effect of ESC-EVs was further investigated in vivo by injection into aged mice. The results showed that ESC-EVs successfully ameliorated the pathological age-related phenotypes and rescued the transcriptome profile of aged mice. Our findings demonstrate that ESC-EVs treatment can rejuvenate senescence both in vitro and in vivo and suggest the therapeutic potential of ESC-EVs as a novel cell-free alternative to ESCs for age-related diseases.

茂名市| 蓝山县| 红河县| 广丰县| 广丰县| 靖远县| 扬中市| 辽阳市| 越西县| 永城市| 石楼县| 汝南县| 金昌市| 玉山县| 云阳县| 元朗区| 平乡县| 云安县| 上思县| 丽江市| 民勤县| 剑川县| 秦安县| 平塘县| 温宿县| 大埔区| 阳江市| 永兴县| 潜山县| 定兴县| 永平县| 奉新县| 石家庄市| 开封县| 惠来县| 淮北市| 台南市| 金堂县| 石景山区| 尉犁县| 开鲁县|