一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Bioactive Materials >>article
Bioactive Materials

Bioactive Materials

IF: 18
Download PDF

Embryonic stem cell-derived extracellular vesicles rejuvenate senescent cells and antagonize aging in mice

Published:1 July 2023 DOI: PMID: 37449253
Lu Yu , Hang Wen , Chang Liu , Chen Wang , Huaxin Yu , Kaiyue Zhang , Qingsheng Han , Yue Liu , Zhongchao Han , Zongjin Li , Na Liu

Abstract

Aging is a degenerative process that leads to tissue dysfunction and death. Embryonic stem cells (ESCs) have great therapeutic potential for age-related diseases due to their capacity for self-renewal and plasticity. However, the use of ESCs in clinical treatment is limited by immune rejection, tumourigenicity and ethical issues. ESC-derived extracellular vesicles (EVs) may provide therapeutic effects that are comparable to those of ESCs while avoiding unwanted effects. Here, we fully evaluate the role of ESC-EVs in rejuvenation in vitro and in vivo. Using RNA sequencing (RNA-Seq) and microRNA sequencing (miRNA-Seq) screening, we found that miR-15b-5p and miR-290a-5p were highly enriched in ESC-EVs, and induced rejuvenation by silencing the Ccn2-mediated AKT/mTOR pathway. These results demonstrate that miR-15b-5p and miR-290a-5p function as potent activators of rejuvenation mediated by ESC-EVs. The rejuvenating effect of ESC-EVs was further investigated in vivo by injection into aged mice. The results showed that ESC-EVs successfully ameliorated the pathological age-related phenotypes and rescued the transcriptome profile of aged mice. Our findings demonstrate that ESC-EVs treatment can rejuvenate senescence both in vitro and in vivo and suggest the therapeutic potential of ESC-EVs as a novel cell-free alternative to ESCs for age-related diseases.

进贤县| 金平| 黄大仙区| 涿鹿县| 日土县| 新津县| 乐清市| 富宁县| 花莲市| 灌阳县| 曲周县| 苍山县| 宕昌县| 寻乌县| 香格里拉县| 渝中区| 房山区| 汾西县| 景德镇市| 亚东县| 江华| 团风县| 阜城县| 泗阳县| 怀安县| 霍林郭勒市| 台东县| 山阳县| 东港市| 石嘴山市| 阿合奇县| 佛山市| 瑞安市| 惠来县| 郴州市| 固镇县| 兴宁市| 石狮市| 汶上县| 崇阳县| 滦平县|