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International Journal of Molecular Sciences

International Journal of Molecular Sciences

IF: 5.6
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The Mechanism of Tigecycline Resistance in Acinetobacter baumannii Revealed by Proteomic and Genomic Analysis

Published:12 May 2023 DOI: 10.3390/ijms24108652 PMID: 37239993
Cunwei Liu, Lei Wang, Ping Wang, Di Xiao, Qinghua Zou

Abstract

The mechanism of tigecycline resistance in A. baumannii remains largely unclear. In this study, we selected a tigecycline-resistant and a tigecycline-susceptible strain from a tigecycline-susceptible and a resistant strain, respectively. Proteomic and genomic analyses were performed to elucidate the variations associated with tigecycline resistance. Our study showed proteins associated with efflux pump, biofilm formation, iron acquisition, stress response, and metabolic ability are upregulated in tigecycline resistant strains, and efflux pump should be the key mechanism for tigecycline resistance. By genomic analysis, we found several changes in the genome that can explain the increased level of efflux pump, including the loss of the global negative regulator hns in the plasmid and the disruption of the hns gene and acrR gene on the chromosome by the insertion of IS5. Collectively, we not only revealed the phenomenon that the efflux pump is mainly responsible for tigecycline resistance, but also highlighted the mechanism at the genomic level, which will help in understanding the resistance mechanism in detail and provide clues for the treatment of clinical multiple drug-resistant A. baumannii.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE 555-60-2 C9H5ClN4 219 suppliers $16.00-$1900.00
CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE 555-60-2 C9H5ClN4 219 suppliers $16.00-$1900.00
CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE 555-60-2 C9H5ClN4 219 suppliers $16.00-$1900.00
CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE 555-60-2 C9H5ClN4 219 suppliers $16.00-$1900.00
H-Phe-Arg-βNA · 2 HCl 100929-99-5 C25H32Cl2N6O2 112 suppliers $43.00-$1595.00
H-Phe-Arg-βNA · 2 HCl 100929-99-5 C25H32Cl2N6O2 112 suppliers $43.00-$1595.00
H-Phe-Arg-βNA · 2 HCl 100929-99-5 C25H32Cl2N6O2 112 suppliers $43.00-$1595.00
H-Phe-Arg-βNA · 2 HCl 100929-99-5 C25H32Cl2N6O2 112 suppliers $43.00-$1595.00
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