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ChemicalBook >> CAS DataBase List >> GSK-2126458

GSK-2126458

GSK-2126458 price.
  • $23 - $8373.75
  • Product name: GSK-2126458
  • CAS: 1086062-66-9
  • MF: C25H17F2N5O3S
  • MW: 505.5
  • EINECS:629-873-1
  • MDL Number:MFCD16038929
  • Synonyms:GSK-2126458;GSK2126458; GSK-2126458;2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide;HYR-582;GSK212;2,4-Difluoro-N-[2-Methoxy-5-[4-(pyridazin-4-yl)quinolin-6-yl]pyridin-3-yl]benzenesulfonaMide;GSK458;Omipalisib (GSK2126458, GSK458)
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Brand
  • aablocks
  • ACHEMBLOCK
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
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  • Biorbyt Ltd
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  • Crysdot
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  • Sigma-Aldrich
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  • TRC
Package
  • 10mM(in1mLDMSO)
  • 2mg
  • 5mg
  • 10mg
  • 50
  • 1mg
  • 10mM(in 1mL DMSO)
  • 10mM*1mLinDMSO
  • 25.00mg
  • 25mg
  • 50mg
  • 2x25mg
  • 100mg
  • 100.00mg
  • 250mg
  • 1g
  • 1000mg
  • Manufactureraablocks
  • Product numberAA008TDY
  • Product descriptionOmipalisib 98%
  • Packaging10mg
  • Price$70
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008TDY
  • Product descriptionOmipalisib 95
  • Packaging25mg
  • Price$163
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA008TDY
  • Product descriptionOmipalisib 98%
  • Packaging50mg
  • Price$207
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008TDY
  • Product descriptionOmipalisib 95%
  • Packaging100mg
  • Price$246
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008TDY
  • Product descriptionOmipalisib 95%
  • Packaging250mg
  • Price$413
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008TDY
  • Product descriptionOmipalisib 95%
  • Packaging1g
  • Price$1096
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008TDY
  • Product descriptionOmipalisib 98%
  • Packaging5mg
  • Price$42
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008TDY
  • Product descriptionOmipalisib 98%
  • Packaging2mg
  • Price$31
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008TDY
  • Product descriptionOmipalisib 98%
  • Packaging1mg
  • Price$23
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10327
  • Product descriptionGSK2126458 98%
  • Packaging100MG
  • Price$400
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10327
  • Product descriptionGSK2126458 98%
  • Packaging100MG
  • Price$400
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10327
  • Product descriptionGSK2126458 98%
  • Packaging25MG
  • Price$170
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10327
  • Product descriptionGSK2126458 98%
  • Packaging25MG
  • Price$170
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10327
  • Product descriptionGSK2126458 98%
  • Packaging1G
  • Price$1200
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10327
  • Product descriptionGSK2126458 98%
  • Packaging1G
  • Price$1200
  • Updated2026-05-27
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1126-M001
  • Product descriptionGSK2126458 ≥95%
  • Packaging1mg
  • Price$157
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA008TDY Omipalisib 98% 10mg $70 2026-05-28 Buy
aablocks AA008TDY Omipalisib 95 25mg $163 2026-05-28 Buy
aablocks AA008TDY Omipalisib 98% 50mg $207 2026-05-28 Buy
aablocks AA008TDY Omipalisib 95% 100mg $246 2026-05-28 Buy
aablocks AA008TDY Omipalisib 95% 250mg $413 2026-05-28 Buy
aablocks AA008TDY Omipalisib 95% 1g $1096 2026-05-28 Buy
aablocks AA008TDY Omipalisib 98% 5mg $42 2026-05-28 Buy
aablocks AA008TDY Omipalisib 98% 2mg $31 2026-05-28 Buy
aablocks AA008TDY Omipalisib 98% 1mg $23 2026-05-28 Buy
ACHEMBLOCK 10327 GSK2126458 98% 100MG $400 2026-05-25 Buy
ACHEMBLOCK 10327 GSK2126458 98% 100MG $400 2026-05-27 Buy
ACHEMBLOCK 10327 GSK2126458 98% 25MG $170 2026-05-25 Buy
ACHEMBLOCK 10327 GSK2126458 98% 25MG $170 2026-05-27 Buy
ACHEMBLOCK 10327 GSK2126458 98% 1G $1200 2026-05-25 Buy
ACHEMBLOCK 10327 GSK2126458 98% 1G $1200 2026-05-27 Buy
Adipogen Life Sciences SYN-1126-M001 GSK2126458 ≥95% 1mg $157 2026-05-06 Buy

Properties

Melting point :187-189℃
Boiling point :715.6±70.0 °C(Predicted)
Density :1.45
storage temp. :Refrigerator
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated)
form :Solid
pka :6.23±0.40(Predicted)
color :White to Pale Yellow
InChI :InChI=1S/C25H17F2N5O3S/c1-35-25-23(32-36(33,34)24-5-3-18(26)12-21(24)27)11-17(13-29-25)15-2-4-22-20(10-15)19(7-8-28-22)16-6-9-30-31-14-16/h2-14,32H,1H3
InChIKey :CGBJSGAELGCMKE-UHFFFAOYSA-N
SMILES :C1(S(NC2=CC(C3=CC=C4C(=C3)C(C3=CC=NN=C3)=CC=N4)=CN=C2OC)(=O)=O)=CC=C(F)C=C1F

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)Health Hazard (GHS08)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively). It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110α. GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models. GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 to suppress the growth of SNU-1040 colorectal cancer cells.

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