ML355
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- $32 - $1996
- Product name: ML355
- CAS: 1532593-30-8
- MF: C21H19N3O4S2
- MW: 441.52
- EINECS:
- MDL Number:MFCD28167822
- Synonyms:ML355;N-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide;ML 355;ML-355;ML355;N-(benzo[d]thiazol-2-yl)-4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide;Benzenesulfonamide, N-2-benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-;ML355,LOX,ML-355,Lipoxygenase,Inhibitor,inhibit,ML 355;12-LOX enzyme inhibitor;VLX 1005
61 prices
Selected condition：
Brand
- aablocks
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 2mg
- 10mM*1mLinDMSO(Solution)
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA00ABI2
- Product descriptionN-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide 98%
- Packaging1mg
- Price$32
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABI2
- Product descriptionN-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide 98%
- Packaging2mg
- Price$39
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABI2
- Product descriptionN-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide 98%
- Packaging5mg
- Price$51
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABI2
- Product descriptionN-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide 98%
- Packaging10mg
- Price$65
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABI2
- Product descriptionN-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide 98%
- Packaging25mg
- Price$85
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABI2
- Product descriptionN-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide 98%
- Packaging50mg
- Price$110
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABI2
- Product descriptionN-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide 98%
- Packaging100mg
- Price$186
- Updated2026-05-28
- Buy
- ManufacturerAK Scientific
- Product number1927DU
- Product descriptionCID70701426
- Packaging10mg
- Price$468
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA764546
- Product descriptionML355 98+%
- Packaging5mg
- Price$143
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA764546
- Product descriptionML355 98+%
- Packaging10mg
- Price$198
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA764546
- Product descriptionML355 98+%
- Packaging25mg
- Price$335
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA764546
- Product descriptionML355 98+%
- Packaging2mg
- Price$98
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB8014
- Product descriptionML355
- Packaging5mg
- Price$160
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB8014
- Product descriptionML355
- Packaging10mg
- Price$260
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB8014
- Product descriptionML355
- Packaging25mg
- Price$530
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB8014
- Product descriptionML355
- Packaging50mg
- Price$910
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00ABI2 | N-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide 98% | 1mg | $32 | 2026-05-28 | Buy |
| aablocks | AA00ABI2 | N-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide 98% | 2mg | $39 | 2026-05-28 | Buy |
| aablocks | AA00ABI2 | N-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide 98% | 5mg | $51 | 2026-05-28 | Buy |
| aablocks | AA00ABI2 | N-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide 98% | 10mg | $65 | 2026-05-28 | Buy |
| aablocks | AA00ABI2 | N-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide 98% | 25mg | $85 | 2026-05-28 | Buy |
| aablocks | AA00ABI2 | N-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide 98% | 50mg | $110 | 2026-05-28 | Buy |
| aablocks | AA00ABI2 | N-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide 98% | 100mg | $186 | 2026-05-28 | Buy |
| AK Scientific | 1927DU | CID70701426 | 10mg | $468 | 2021-12-16 | Buy |
| Ambeed | A764546 | ML355 98+% | 5mg | $143 | 2021-12-16 | Buy |
| Ambeed | A764546 | ML355 98+% | 10mg | $198 | 2021-12-16 | Buy |
| Ambeed | A764546 | ML355 98+% | 25mg | $335 | 2021-12-16 | Buy |
| Ambeed | A764546 | ML355 98+% | 2mg | $98 | 2021-12-16 | Buy |
| ApexBio Technology | B8014 | ML355 | 5mg | $160 | 2026-05-06 | Buy |
| ApexBio Technology | B8014 | ML355 | 10mg | $260 | 2026-05-06 | Buy |
| ApexBio Technology | B8014 | ML355 | 25mg | $530 | 2026-05-06 | Buy |
| ApexBio Technology | B8014 | ML355 | 50mg | $910 | 2026-05-06 | Buy |
Properties
Melting point :>182°C (dec.)
Boiling point :654.5±65.0 °C(Predicted)
Density :1.481±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Pyridine (Very Slightly)
form :Solid
pka :7.58±0.30(Predicted)
color :Pale Beige to Beige
Boiling point :654.5±65.0 °C(Predicted)
Density :1.481±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Pyridine (Very Slightly)
form :Solid
pka :7.58±0.30(Predicted)
color :Pale Beige to Beige
Safety Information
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Description
Platelet-type 12-lipoxygenase (12-LO; ) catalyzes the formation of 12-HpETE from arachidonic acid . It has been found to be expressed in various tumor cells as well as pancreatic islets and can be activated by inflammatory cytokines. It has also been implicated in the modulation of hemostasis and thrombosis through its role in regulating platelet function. ML355 is a selective inhibitor of 12-LO with an IC50 value of 0.34 μM. It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = 9.7, >100, and >100 μM) and no inhibition of COX-1 and -2. In cell-based assays, ML355 has been shown to decrease calcium mobilization and thrombin receptor PAR4-induced platelet aggregation in patient-derived human platelets and to significantly inhibit arachidonic acid and calcium- ionophore-induced 12-HpETE synthesis in mouse BTC3 cells and human islets.More related product prices
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