RG108
|
- $20 - $2416
- Product name: RG108
- CAS: 48208-26-0
- MF: C19H14N2O4
- MW: 334.33
- EINECS:
- MDL Number:MFCD08705332
- Synonyms:(S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;RG108/RG-108;(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;N-Phthaloyl-L-tryptophan;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-;N-Phthaloyl-L-tryptophan (S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;DNA Methyltransferase Inhibitor;N-Phthalyl-L-tryptophan
97 prices
Selected condition:
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biosynth
- Cayman Chemical
- Chemenu
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Labseeker
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- Thermo Scientific Chemicals
- TRC
- Usbiological
Package
- 2x50mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 2x10mg
- 200MG
- 10mM*1mLinDMSO(Solution)
- 20mg
- 500mg
- 50.00g
- 100.00g
- 10mM*1mLinDMSO
- 250.00g
- 1mg
- 10mM(in 1mL DMSO)
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 5g
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA003U1M
- Product descriptionN-Phthalyl-L-tryptophan 98%
- Packaging1mg
- Price$20
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003U1M
- Product descriptionN-Phthalyl-L-tryptophan 98%
- Packaging5mg
- Price$29
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003U1M
- Product descriptionN-Phthalyl-L-tryptophan 98%
- Packaging10mg
- Price$36
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003U1M
- Product descriptionN-Phthalyl-L-tryptophan 98%
- Packaging50mg
- Price$53
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003U1M
- Product descriptionN-Phthalyl-L-tryptophan 95%
- Packaging100mg
- Price$55
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003U1M
- Product descriptionN-Phthalyl-L-tryptophan 95%
- Packaging250mg
- Price$116
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003U1M
- Product descriptionN-Phthalyl-L-tryptophan 97%
- Packaging1g
- Price$402
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003U1M
- Product descriptionN-Phthalyl-L-tryptophan 97%
- Packaging5g
- Price$1564
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33720
- Product descriptionRG108 98%
- Packaging5G
- Price$1250
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33720
- Product descriptionRG108 98%
- Packaging100MG
- Price$95
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33720
- Product descriptionRG108 98%
- Packaging1G
- Price$350
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberSYN3037
- Product descriptionRG-108
- Packaging10mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA548158
- Product descriptionRG108 98+%
- Packaging5mg
- Price$42
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA548158
- Product descriptionRG108 98+%
- Packaging10mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA548158
- Product descriptionRG108 98+%
- Packaging50mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA548158
- Product descriptionRG108 98+%
- Packaging250mg
- Price$162
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA003U1M | N-Phthalyl-L-tryptophan 98% | 1mg | $20 | 2026-05-28 | Buy |
| aablocks | AA003U1M | N-Phthalyl-L-tryptophan 98% | 5mg | $29 | 2026-05-28 | Buy |
| aablocks | AA003U1M | N-Phthalyl-L-tryptophan 98% | 10mg | $36 | 2026-05-28 | Buy |
| aablocks | AA003U1M | N-Phthalyl-L-tryptophan 98% | 50mg | $53 | 2026-05-28 | Buy |
| aablocks | AA003U1M | N-Phthalyl-L-tryptophan 95% | 100mg | $55 | 2026-05-28 | Buy |
| aablocks | AA003U1M | N-Phthalyl-L-tryptophan 95% | 250mg | $116 | 2026-05-28 | Buy |
| aablocks | AA003U1M | N-Phthalyl-L-tryptophan 97% | 1g | $402 | 2026-05-28 | Buy |
| aablocks | AA003U1M | N-Phthalyl-L-tryptophan 97% | 5g | $1564 | 2026-05-28 | Buy |
| ACHEMBLOCK | O33720 | RG108 98% | 5G | $1250 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33720 | RG108 98% | 100MG | $95 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33720 | RG108 98% | 1G | $350 | 2026-05-27 | Buy |
| AK Scientific | SYN3037 | RG-108 | 10mg | $130 | 2021-12-16 | Buy |
| Ambeed | A548158 | RG108 98+% | 5mg | $42 | 2021-12-16 | Buy |
| Ambeed | A548158 | RG108 98+% | 10mg | $55 | 2021-12-16 | Buy |
| Ambeed | A548158 | RG108 98+% | 50mg | $88 | 2021-12-16 | Buy |
| Ambeed | A548158 | RG108 98+% | 250mg | $162 | 2021-12-16 | Buy |
Properties
Melting point :192-194℃
Boiling point :606.0±50.0 °C(Predicted)
Density :1.502±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >10mg/mL
pka :3.62±0.10(Predicted)
form :powder
color :yellow
optical activity :[α]/D -250 to -310°, c =0.5 in methanol
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI :1S/C19H16N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h3-8,10,16,20H,1-2,9H2,(H,24,25)/t16-/m0/s1
InChIKey :LMAZUAXDZRILNJ-INIZCTEOSA-N
SMILES :OC(=O)[C@H](Cc1c[nH]c2ccccc12)N3C(=O)C4=CCCC=C4C3=O
CAS DataBase Reference :48208-26-0
Boiling point :606.0±50.0 °C(Predicted)
Density :1.502±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >10mg/mL
pka :3.62±0.10(Predicted)
form :powder
color :yellow
optical activity :[α]/D -250 to -310°, c =0.5 in methanol
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI :1S/C19H16N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h3-8,10,16,20H,1-2,9H2,(H,24,25)/t16-/m0/s1
InChIKey :LMAZUAXDZRILNJ-INIZCTEOSA-N
SMILES :OC(=O)[C@H](Cc1c[nH]c2ccccc12)N3C(=O)C4=CCCC=C4C3=O
CAS DataBase Reference :48208-26-0
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||||||
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Description
DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro). It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site. Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes.Related product price
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