1,1,3,3-Tetramethylurea synthesis
- Product Name:1,1,3,3-Tetramethylurea
- CAS Number:632-22-4
- Molecular formula:C5H12N2O
- Molecular Weight:116.16
32315-10-9
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124-40-3
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$18.00/100ml
632-22-4
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$6.00/10g
Yield:632-22-4 92%
Reaction Conditions:
in dichloromethane;water at 15 - 20;Large scale;
Steps:
1 Embodiment 1
To the three-mouth flask is added dimethylamine aqueous solution (40%, 3 . 81 kg, 33.8 μM), ice salt bath to control the temperature 15 °C following dropwise triphosgene (773.4 g, 2.6 μM) of the dichloromethane solution, after the drop to, the natural recovery of the reaction liquid to room temperature to continue the reaction 2 - 3 hours, after the reacting liquid clarification, liquid, DCM extraction the aqueous phase, and then combined dichloromethane phase, the combined dichloromethane uses full and salt water washing, and thereafter drying, filtering, concentrating, oil pump vacuum distillation and drying to obtain 836 g colorless liquid, GC purity is greater than 99%, yield is 92%.
References:
Suzhou Haofan Biological Co., Ltd.;Jiang Zhaoqin;Li Honglin CN108558706, 2018, A Location in patent:Paragraph 0052-0054; 0057; 0058; 006; 0062; 0065; 0066
2782-91-4
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632-22-4
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67-66-3
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124-40-3
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$18.00/100ml
632-22-4
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$6.00/10g
124-38-9
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124-40-3
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632-22-4
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$6.00/10g
201230-82-2
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124-40-3
543 suppliers
$18.00/100ml
632-22-4
331 suppliers
$6.00/10g