1-Hydroxybenzotriazole synthesis
- Product Name:1-Hydroxybenzotriazole
- CAS Number:2592-95-2
- Molecular formula:C6H5N3O
- Molecular Weight:135.12
98-95-3
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2592-95-2
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Yield:2592-95-2 90.1%
Reaction Conditions:
with hydrogenchloride;sodium carbonate in water;toluene;
Steps:
1 Example 1
Example 1 150 g of hiydrazine hydrate and 106.5 g of sodium carbonate (99.5% strength) were initially taken in a stirred flask and heated to about 90° C. In the course of 70 min, 175.5 g of molten o-nitrobenzene were added dropwise. Thereafter, the mixture was stirred 4.5 hours at 100° C. and for a further 2 hours at 105° C. After the addition of 350 ml of water, a clear solution was obtained and was stirred tlioroughly with two portions each of 150 ml of toluene. Residual toluene was removed by partial distillation of the aqueous phase, and the aqueous phase was acidified with 260 ml of concentrated hydrochloric acid to pH 1. The mixture containing the precipitated 1-hydroxy-benzotriazole was cooled to 5° C., filtered off with suction and washed chloride-free with water. The yield was 90.1% of the theoretical yield.
References:
US5998628,1999,A
88-73-3
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2592-95-2
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95-14-7
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$6.00/100g
2592-95-2
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2075-46-9
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$6.00/5g
2592-95-2
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3034-19-3
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2592-95-2
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