1-(2-Methoxyphenyl)piperazine hydrobromide synthesis
- Product Name:1-(2-Methoxyphenyl)piperazine hydrobromide
- CAS Number:100939-96-6
- Molecular formula:C11H17BrN2O
- Molecular Weight:273.17
35386-24-4
316 suppliers
$13.00/1g
100939-96-6
171 suppliers
$85.00/500mg
Yield:100939-96-6 96.74%
Reaction Conditions:
with hydrogen bromide in methanol at -15 - 5; for 2.5 h;Solvent;Temperature;
Steps:
9-12; 4 Example 9
Urapidil intermediate 1-(2-methoxyphenyl)piperazine obtained in Example 1 is used to prepare a urapidil intermediate 1-(2-methoxyphenyl)piperazine hydrobromide, The specific operations are as follows:In a 1000mL four-necked flask, add methanol 300mL and 1-(2-methoxyphenyl)piperazine 50g, turn on stirring, control the temperature to 5°C, and drip 148.7mL concentration of 150g/L hydrogen bromide methanol solution in 30min. , cooled to -15°C for 120min after the dropwise addition was completed, and after suction filtration and drying, urapidil intermediate 1-(2-methoxyphenyl)piperazine hydrobromide 68.73g was obtained, yield 96.74%, melting range 232.6-234.4, HPLC purity 99.50%
References:
CN114685399,2022,A Location in patent:Paragraph 0091-0102; 0109-0110
90-05-1
808 suppliers
$5.00/1g
100939-96-6
171 suppliers
$85.00/500mg