ChemicalBook CAS DataBase List 1-(3-Nitrophenyl)piperazine

1-(3-Nitrophenyl)piperazine synthesis

6synthesis methods

Product Name:1-(3-Nitrophenyl)piperazine
CAS Number:54054-85-2
Molecular formula:C10H13N3O2
Molecular Weight:207.23

110-85-0

402-67-5

54054-85-2

1. 28.4 g (0.33 mol, 5.5 equiv) of piperazine is dissolved in 50 mL of DMSO. 2. 6.4 mL (60 mmol) of m-fluoronitrobenzene is added to this solution. 2. 6.4 mL (60 mmol) of m-fluoronitrobenzene was added to the above solution. 3. The reaction mixture was heated at 100°C for 60 hours. 4. 4. When the reaction is complete, cool to room temperature and slowly pour the mixture into 530 mL of water. 5. The precipitate formed was collected by filtration and the filtrate was extracted with ether (Et2O). 6. 6. The organic phases were combined, dried over anhydrous magnesium sulfate (MgSO4), and concentrated under reduced pressure. 7. The crude product was purified by column chromatography using a solvent mixture of dichloromethane (CH2Cl2) and methanol (MeOH) (9:1, v/v/v) as eluent. 8. The target component was collected and concentrated under reduced pressure to give 8.04 g of orange oil, which was crystallized as 1-(3-nitrophenyl)piperazine after standing at room temperature in 65% yield. Compound characterization data. Molecular formula: C10H13N3O2 Molecular weight: 207.26 g/mol 1H NMR (CDCl3) δ (ppm): 7.70 (t, J = 2 Hz, 1H, H-2'); 7.64 (ddd, J = 8 Hz, 2 Hz, 0.6 Hz, 1H, H-4'); 7.36 (t, J = 8 Hz, 1H, H-5'); 7.17 (ddd, J = 8 Hz, 2 Hz, 0.6 Hz, 1H, H-6') ; 3.30-3.18 (m, 4H, H-3, H-5); 3.09-2.97 (m, 4H, H-2, H-6).

110-85-0 Synthesis

110-85-0
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$5.00/5 g

402-67-5 Synthesis

402-67-5
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$6.00/5g

54054-85-2
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$17.67/1gm:

Yield: 72%

Reaction Conditions:

with potassium carbonate in dimethyl sulfoxide at 100; for 24 h;

Steps:

2-1; 3.1
A mixture of piperazine (12 g, 138 mmol), 1-fluoro-3-nitrobenzene (4 ml, 34 mmol) and potassium carbonate (9.60 g, 69 mmol) in DMSO (40 mL) is heated at 100°C for 24 h. The reaction is quenched with H₂O (60 mL) and extracted with Et₂O (3 x 20 mL). The organic layer is washed with brine (20 mL) and dried over Na₂SO₄ and concentrated in vacuo. The residue is chromatographied on silica gel eluting with CH₂Cl₂/ MeOH (94 / 6) to yield the title compound (5.15 g, 72%) as an orange solid. This solid was dissolved in CH₂Cl₂ and Boc₂O (6 g, 130 mmol) was added. The mixture was stirred overnight. The solvent was evaporated and the residual solid was crystallized in heptane (6.80 g, 93%, mp 86°C). ¹H NMR (200 MHz, CDCl₃) δ 1.49 (s, 9 H), 3.22-3.27 (m, 4 H), 3.58-3.63 (m, 4 H), 7.16-7.71 (m, 4 H).