Bis(2-chloroethyl)amine hydrochloride synthesis
- Product Name:Bis(2-chloroethyl)amine hydrochloride
- CAS Number:821-48-7
- Molecular formula:C4H10Cl3N
- Molecular Weight:178.49
111-42-2
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Yield:821-48-7 100%
Reaction Conditions:
with thionyl chloride in 1,2-dichloro-ethane at 50; for 3 h;
Steps:
1
Into a 1 L flask, equipped a refluxing condenser, is added 31.5 g (0.30 mole) of diethanolamine and 300 mL of dichloroethane, then 51.0 mL of thionyl chloride. Solid suspension formed immediately after the addition of thionyl chloride and then dissolved upon warming to 50° C. During refluxing, the solid suspension is dissolved and then the crystalline solid appears. The crystalline suspension is refluxed while being stirred for 3 hrs. The reaction is quenched by adding 20 mL of methanol and the solvents are removed under vacuum. A white crystalline material, bis(2-chloroethyl)amine hydrochloride, weighted 53.0 g, is obtained in a quantitative yield.
References:
Hu, Songzhou US2015/299113, 2015, A1 Location in patent:Paragraph 0043
15567-79-0
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821-48-7
568 suppliers
$6.00/25g