一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List tert-Butyl 4-((6-bromopyridin-3-yl)methyl)piperazine-1-carboxylate
1160923-86-3

tert-Butyl 4-((6-bromopyridin-3-yl)methyl)piperazine-1-carboxylate synthesis

1synthesis methods
149806-06-4 Synthesis
2-Bromopyridine-5-carbaldehyde

149806-06-4
440 suppliers
$5.00/1g

57260-71-6 Synthesis
1-BOC-Piperazine

57260-71-6
719 suppliers
$5.00/5g

tert-Butyl 4-((6-bromopyridin-3-yl)methyl)piperazine-1-carboxylate

1160923-86-3
25 suppliers
inquiry

-

Yield:1160923-86-3 78%

Reaction Conditions:

with sodium tris(acetoxy)borohydride;acetic acid in dichloromethane at 15 - 25; for 24 h;

Steps:

t-Butyl 4-((6-bromopyridin-3-yl)methyl)piperazine-l-carboxylate (iii)

A solution of 5-bromopyridine-2-carbaldehyde (i; 71.4 g, 384 mmol, 1 equiv), 1-Boc- piperzine (ii; 72.8 g, 391 mmol, 1.02 equiv), dichloromethane (1.2 L), and acetic acid (2.4 mL) was cooled to 15 °C and sodium triacetoxyborohydride (164.9 g, 777.8 mmol, 2.03 equiv) was added portionwise to the mixture at 25 °C. The resulting solution was stirred for 24 h at room temperature. An additional portion of sodium triacetoxyborohydride (13 g, 61.3 mmol, 0.16 equiv) was added portionwise at 15 °C. The reaction was then quenched with aq 2N NaOH (250 mL) and the resulting solution was stirred for another 0.5 h. The organic layer was washed twice with water, dried and concentrated. The residue was recrystallized with 4:1 petroleum ether/ethyl acetate to yield 107.7 g (78% yield) of iii as a light yellow solid.

References:

WO2019/148161,2019,A1 Location in patent:Page/Page column 22; 23

tert-Butyl 4-((6-bromopyridin-3-yl)methyl)piperazine-1-carboxylate Related Search:

城固县| 定南县| 新蔡县| 宁远县| 收藏| 原平市| 恭城| 香格里拉县| 北碚区| 崇明县| 天祝| 蕉岭县| 九龙坡区| 宝丰县| 四子王旗| 兴城市| 鄂尔多斯市| 银川市| 钟山县| 洛阳市| 稻城县| 张家口市| 德州市| 嘉定区| 卓资县| 呼伦贝尔市| 水富县| 曲松县| 疏勒县| 乌拉特中旗| 广昌县| 邵武市| 濉溪县| 北京市| 固原市| 汕尾市| 沈丘县| 大石桥市| 嵊泗县| 华阴市| 措美县|