2-(2,4-DIFLUOROPHENOXY)ACETOHYDRAZIDE synthesis
- Product Name:2-(2,4-DIFLUOROPHENOXY)ACETOHYDRAZIDE
- CAS Number:588676-13-5
- Molecular formula:C8H8F2N2O2
- Molecular Weight:202.16
717-30-6
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Yield:-
Reaction Conditions:
with hydrazine hydrate in ethanol;Reflux;
Steps:
General procedure for intermediates 14
General procedure: Intermediates 14 were prepared by following the knownprocedure [22, 29, 30]. The mixture of ethyl 2-chloroacetate(1 mmol), substituted phenols (1 mmol), and K2CO3(1.2 mmol) in acetonitrile was stirred in refluxing for 2 h(the course of the reactions was monitored by TLC), thenfiltered, and the mother liquid was evaporated in vacuo toafford corresponding substituted ethyl 2-phenoxyacetates,which were then reacted with hydrazine hydrate (80%) toyield substituted 2-phenoxyacetohydrazides 14 in>90%yield.
References:
Wang, Yanyan;Lu, Xiumian;Shi, Jun;Xu, Jiahong;Wang, Fenghua;Yang, Xiao;Yu, Gang;Liu, Zhiqian;Li, Chuanhui;Dai, Ali;Zhao, Yonghui;Wu, Jian [Monatshefte fur Chemie,2018,vol. 149,# 3,p. 611 - 623]
367-27-1
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588676-13-5
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