2,3-Difluorobenzoylacetonitrile synthesis
- Product Name:2,3-Difluorobenzoylacetonitrile
- CAS Number:267880-87-5
- Molecular formula:C9H5F2NO
- Molecular Weight:181.14
18355-74-3
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Yield:267880-87-5 63%
Reaction Conditions:
Stage #1: acetonitrilewith n-butyllithium in tetrahydrofuran at -78; for 1.03333 h;Inert atmosphere;
Stage #2: methyl 2,3-difluorobenzoate in tetrahydrofuran at -78 - 20; for 2.5 h;Inert atmosphere;
References:
Marcyk, Paul T.;Leblanc, Emmanuelle V.;Kuntz, Douglas A.;Xue, Alice;Ortiz, Francisco;Trilles, Richard;Bengtson, Stephen;Kenney, Tristan M. G.;Huang, David S.;Robbins, Nicole;Williams, Noelle S.;Krysan, Damian J.;Privé, Gilbert G.;Whitesell, Luke;Cowen, Leah E.;Brown, Lauren E. [Journal of Medicinal Chemistry,2021,vol. 64,# 2,p. 1139 - 1169]
