2,4-Dichlorobenzyl chloride synthesis
- Product Name:2,4-Dichlorobenzyl chloride
- CAS Number:94-99-5
- Molecular formula:C7H5Cl3
- Molecular Weight:195.47
1777-82-8
94-99-5
GENERAL STEPS: 2,4-dichlorobenzyl alcohol (17.7 g, 0.1 mol), dichloromethane (30 mL), and N,N-dimethylformamide (DMF, 1 mL) were added to a 100 mL round-bottomed flask, followed by the slow dropwise addition of phosphorus trichloride (4.68 g, 0.034 mol). The reaction mixture was heated to reflux temperature (60-80°C) and the reaction lasted for 2-3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) until the complete disappearance of the raw material. After completion of the reaction, 2,4-dichlorobenzyl chloride (17.99 g, 92% yield) was purified by distillation.
1777-82-8
431 suppliers
$6.00/5g
94-99-5
382 suppliers
$5.00/10g
Yield:94-99-5 92%
Reaction Conditions:
with phosphorus trichloride in dichloromethane;N,N-dimethyl-formamide at 60 - 80;Reagent/catalyst;
Steps:
6 Example 6
To a 100 mL round bottom flask was added 2,4-dichlorobenzyl alcohol (17.7 g, 0.1 mol) and dichloromethane (30 mL) andDMF (1 mL), followed by the addition of phosphorus trichloride (4.68 g, 0.034 mol) and slowly warming to reflux (60-80 ° C) Should be 2 ~ 3h, TLC detection shows the disappearance of raw materials, distillation was 2,4-dichlorobenzene 17.99g, yield 92%.
References:
Zhejiang Yongtai Pharmaceutical Co., Ltd.;Jin Yizhong;He Renbao;Zhou Guobin;Xie Jianren CN106117028, 2016, A Location in patent:Paragraph 0053; 0054; 0055; 0056
95-73-8
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94-99-5
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626-16-4
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94-99-5
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108-88-3
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94-99-5
382 suppliers
$5.00/10g
6574-98-7
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94-99-5
382 suppliers
$5.00/10g