2-(4-HYDROXYPHENYL)PROPIONIC ACID synthesis
- Product Name:2-(4-HYDROXYPHENYL)PROPIONIC ACID
- CAS Number:938-96-5
- Molecular formula:C9H10O3
- Molecular Weight:166.18
156-38-7
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Yield: 80%
Reaction Conditions:
with sulfuric acid in methanol;silica gel;toluene
Steps:
III Methyl(4-Hydroxyphenyl)acetate
Methyl(4-Hydroxyphenyl)acetate A solution of 15 gm (0.1 mole) of 4-hydroxyphenylacetic acid in 500 mL methanol and 2 mL concentrated sulfuric acid was placed in a Soxhlet extractor charged with 3 A molecular sieves. The solution was heated to reflux for 72 hours, and the sieves were exchanged at 24-hour intervals. The reaction medium was then evaporated to an oil which was dissolved in 100 mL toluene and extracted with 3*100 mL water. The toluene phase was dried over magnesium sulfate, treated with activated charcoal and evaporated to provide 13 gm (80% yield) of a yellow oil. The NMR spectrum was consistent with the assigned structure and this material was used in the next reaction step.
References:
American Hospital Supply Corporation US4387103, 1983, A
6420-90-2
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124-38-9
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14140-15-9
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501-97-3
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938-96-5
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