(R)-(+)-2-(4-Hydroxyphenoxy)propionic acid synthesis
- Product Name:(R)-(+)-2-(4-Hydroxyphenoxy)propionic acid
- CAS Number:94050-90-5
- Molecular formula:C9H10O4
- Molecular Weight:182.17
96562-58-2
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94050-90-5
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Yield:94050-90-5 92.3%
Reaction Conditions:
with sodium hydroxide in water at 20; for 3 h;
Steps:
3 Example 3 Preparation of R-(+)-2-(-4-hydroxyphenoxy)propionic acid:
First in 100mL9.8g (0.05mol) was added to the three-necked flaskLight brownMethyl R-(+)-2-(-4-hydroxyphenoxy)propionate,Slowly pour into the prepared 40mL 10% NaOH (2.5 mol / L) while stirringIn the aqueous solution, the system instantly turns dark brown, and the reaction is stirred at room temperature for 3 hours.During the period, TLC was used to track the progress of the reaction (the ratio of the developing agent was V petroleum ether:E-acetate = 3:1, two drops of acetic acid were added dropwise to the developing solvent). The reaction is over,Adjust the pH of the system to 2 to 3, and extract with 40 mL of ethyl acetate. The solution should be taken twice (20 mL each time), the organic phase is combined, and the organic phase is dried and desolventized., a light brown solid is the productR-(+)-2-(-4-hydroxyphenoxy)propionic acid,Drying 8.40g, yield 92.3%,
References:
Zhejiang University of Technology;Tan Chengxia;Yang Sen;Yang Ren;Zhang Donglin CN108821962, 2018, A Location in patent:Paragraph 0041-0042
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