3-(4-Hydroxyphenyl)propionic acid synthesis
- Product Name:3-(4-Hydroxyphenyl)propionic acid
- CAS Number:501-97-3
- Molecular formula:C9H10O3
- Molecular Weight:166.17
7400-08-0
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$29.00/10g
501-97-3
543 suppliers
$10.00/5g
Yield:501-97-3 99%
Reaction Conditions:
Stage #1:para-coumaric acid with palladium diacetate;4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane in ethyl acetate at 25; for 12 h;Schlenk technique;Inert atmosphere;
Stage #2: with hydrogenchloride in water
Steps:
4
Replace the gas environment in the Shrek tube with a nitrogen environment, add 4-hydroxycinnamic acid 0.25 mmol, palladium acetate 0.0025 mmol, ethyl acetate 0.5 mL, add pinacol borane 0.275 mmol under stirring, and react at room temperature for 12 h. After the completion of the reaction, the reaction liquid obtained was diluted with 10 mL of ethyl acetate, 10 mL of saturated sodium bicarbonate was added, extracted three times with ethyl acetate, the pH value of the aqueous phase was adjusted to acidic with concentrated hydrochloric acid, and then extracted with ethyl acetate, and the organic phase was vacuumed Concentrate below to obtain the target product in a yield of> 99% as a white solid.
References:
Zhengzhou University;Cui Xiuling;Wang Yong;Pi Chao;Wu Yangjie CN111099986, 2020, A Location in patent:Paragraph 0034; 0057-0060
7400-08-0
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$29.00/10g
501-97-3
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$10.00/5g
1643-29-4
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$11.00/250mg
501-97-3
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107-13-1
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108-95-2
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501-97-3
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23838-70-2
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501-97-3
543 suppliers
$10.00/5g