2-Amino-3-hydroxypyridine synthesis
- Product Name:2-Amino-3-hydroxypyridine
- CAS Number:16867-03-1
- Molecular formula:C5H6N2O
- Molecular Weight:110.11
6332-56-5
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$10.00/5g
16867-03-1
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$10.00/25g
Yield:16867-03-1 89%
Reaction Conditions:
palladium-carbon in methanol
Steps:
1 a)Preparation of 2-amino-3-hydroxypyridine
a)Preparation of 2-amino-3-hydroxypyridine To a solution of 2-hydroxy-3-nitropyridine (5 g, 45.4 mmol) in methanol(250 ml) was added 10% Pd/C (1 g). The mixture was flushed with argon, then hydrogen was bubbled through the solution for 10 min. and a hydrogen atmosphere was maintained at balloon pressure overnight. The mixture was filtered through celite and the celite was washed with methanol. The solvent was evaporated and chromatography of the resulting solid on silica gel (5% MeOH/CH2Cl2) gave the desired product(3.2 g, 89%). 1H NMR (CD3OD): δ 6.96 (d, 1H), 6.90 (dd, 1H), 6.77 (d, 1H).
References:
SmithKline Beecham Corporation US6218539, 2001, B1
15128-82-2
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16867-03-1
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680-31-9
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611-13-2
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16867-03-1
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680-31-9
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609-38-1
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16867-03-1
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874-24-8
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16867-03-1
589 suppliers
$10.00/25g